Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0225)
Drug Name
Brentuximab vedotin
Synonyms Brentuximab vedotin (USAN); Brentuximab vedotin (genetical recombination) (JAN); Adcetris (TN); D09587; 914088-09-8
Indication Anaplastic large cell lymphoma [ICD11: 2A90] Approved [1]
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Monomethyl Auristatin E (MMAE) DM001450
53297465
Oxidation - Oxidation 1 [3]
Brentuximab vedotin metabolite M1 DM001451 N. A. Oxidation - O-Demethylation 2 [4]
Brentuximab vedotin metabolite M2 DM001452 N. A. Hydrolysis - Amide Hydrolysis 2 [4]
Brentuximab vedotin metabolite M3 DM001453 N. A. Oxidation - Oxidation 2 [4]
Brentuximab vedotin metabolite M4 DM001454 N. A. Oxidation - N-Demethylation 2 [4]
Brentuximab vedotin metabolite M5 DM001455 N. A. Oxidation - Dehydrogenation 2 [4]
Brentuximab vedotin metabolite M6 DM001456 N. A. Oxidation - Demethylation; Oxidation 2 [4]
Brentuximab vedotin metabolite M7 DM001457 N. A. Unclear 2 [4]
Brentuximab vedotin metabolite M8 DM001458 N. A. Unclear 2 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000433 Brentuximab vedotin Monomethyl Auristatin E (MMAE) Oxidation - Oxidation CYP3A4 [3]
MR000425 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M1 Oxidation - O-Demethylation Unclear [4]
MR000426 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M2 Hydrolysis - Amide Hydrolysis Unclear [4]
MR000427 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M3 Oxidation - Oxidation Unclear [4]
MR000428 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M4 Oxidation - N-Demethylation Unclear [4]
MR000429 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M5 Oxidation - Dehydrogenation Unclear [4]
MR000430 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M6 Oxidation - Demethylation; Oxidation Unclear [4]
MR000431 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M7 Unclear Unclear [4]
MR000432 Monomethyl Auristatin E (MMAE) Brentuximab vedotin metabolite M8 Unclear Unclear [4]
⏷ Show the Full List of 9 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Brentuximab Vedotin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Brentuximab vedotin.
3 DrugBank(Pharmacology-Metabolism)Brentuximab vedotin
4 CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies J Clin Pharmacol. 2013 Aug;53(8):866-77. doi: 10.1002/jcph.116.

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