Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0362)
Drug Name
Clotrimazole
Synonyms
Canesten; Canestine; Canifug; Chlotrimazole; Clotrimazol; Clotrimazolum; Desamix F; Empecid; Gyne lotrimin; Gyne-Lotrimin; Gyne-Lotrimin 3; Lotrimin; Lotrimin AF Cream; Lotrimin AF Solution; Lotrimin Af; Mono-baycuten; Monobaycuten; Mycelex; Mycelex 7; Mycelex G; Mycelex OTC; Mycelex Troches; Mycelex-7; Mycelex-G; Mycosporin; Mykosporin; Pedisafe; Rimazole; Tibatin; Trimysten; Trivagizole 3; Veltrim; clotrimazole; (Chlorotrityl)imidazole; 1-(o-Chlorotrityl)imidazole; 23593-75-1; BAY b 5097; Fem Care; Gynix
Indication Candidiasis [ICD11: 1F23] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 344.8 Topological Polar Surface Area 17.8
Heavy Atom Count 25 Rotatable Bond Count 4
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
2812
PubChem SID
9139 ; 569393 ; 602764 ; 3288050 ; 4821019 ; 7847348 ; 7978978 ; 8137259 ; 8149266 ; 8151819 ; 10321221 ; 10514771 ; 10852037 ; 11110962 ; 11110963 ; 11335840 ; 11361079 ; 11364237 ; 11366799 ; 11369361 ; 11371377 ; 11373989 ; 11377523 ; 11447256 ; 11462051 ; 11466295 ; 11467415 ; 11483912 ; 11486069 ; 11487944 ; 11490175 ; 11492110 ; 11495157 ; 11532882 ; 11533491 ; 12146064 ; 14802606 ; 17404878 ; 24278327 ; 24860592 ; 26611668 ; 26680328 ; 26719636 ; 26747486 ; 26747487 ; 26758479 ; 29221967 ; 46386926 ; 46499864 ; 46507927
ChEBI ID
ChEBI:3764
CAS Number
23593-75-1
TTD Drug ID
D09GOS
Formula
C22H17ClN2
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey
VNFPBHJOKIVQEB-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005750 Clotrimazole Unclear Unclear CYP3A4 [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Clotrimazole was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Tacrolimus interaction with clotrimazole: a concise case report and literature review. P T. 2010 Oct;35(10):568-9.
3 [Interest in learning (2)]

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