Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0725)
Drug Name
Fluprednisolone
Synonyms
Fluprednisolonum [INN-Latin]; Isopredon; Alphadrol; Etadrol; FI 6150; Prednisolone, 6alpha-fluoro-; U 7800; U-7800; Vladicort; fluprednisolone; 53-34-9; 6alpha-Fluoro-1-dehydrohydrocortisone; 6alpha-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione; 6alpha-Fluoroprednisolone; 9H05937G3X; B 673; C21H27FO5; CHEBI:34474; Corticosterone, 1-dehydro-6alpha-fluoro-; EINECS 200-170-8; F. I. 6150; HSDB 3335; NCGC00182067-02; NSC 47439; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-, (6alpha,11beta)-; UNII-9H05937G3X
Indication Asthma [ICD11: CA23] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 378.4 Topological Polar Surface Area 94.8
Heavy Atom Count 27 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5876
ChEBI ID
CHEBI:34474
CAS Number
53-34-9
TTD Drug ID
D0V9DZ
Formula
C21H27FO5
Canonical SMILES
CC12CC(C3C(C1CCC2(C(=O)CO)O)CC(C4=CC(=O)C=CC34C)F)O
InChI
1S/C21H27FO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7,12-13,15-16,18,23,25,27H,4,6,8-10H2,1-2H3/t12-,13-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey
MYYIMZRZXIQBGI-HVIRSNARSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013655 Fluprednisolone Unclear Unclear CYP3A4 [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Fluprednisolone was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 NCIthesaurus: Fluprednisolone
3 U. S. FDA Label -Fluprednisolone

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