Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0910)
Drug Name
Lacidipine
Synonyms
Lacidipine; Lacidipine (Lacipil, Motens); Lacidipino; Lacidipino [Spanish]; Lacidipinum [Latin]; Lacimen; Lacipil; Motens; trans Lacidipine; 103890-78-4; 260080034N; 4-(o-((E)-2-Carboxyvinyl)phenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 4-tert-butyl diethyl ester; C26H33NO6; DSSTox_CID_26429; DSSTox_GSID_46429; DSSTox_RID_81607; GR 43659 X; GR 43659X; GR-43659X; GX-1048; UNII-260080034N; diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
Indication Essential hypertension [ICD11: BA00] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 455.5 Topological Polar Surface Area 90.9
Heavy Atom Count 33 Rotatable Bond Count 11
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
5311217
ChEBI ID
CHEBI:94480
CAS Number
103890-78-4
Formula
C26H33NO6
Canonical SMILES
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2C=CC(=O)OC(C)(C)C)C(=O)OCC)C)C
InChI
1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChIKey
GKQPCPXONLDCMU-CCEZHUSRSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Lacidipine metabolite M1 DM002589
22898668
Unclear 1 [3]
Lacidipine metabolite M6 DM002586
50852655
Unclear 1 [3]
Lacidipine metabolite M2 DM002587
101623329
Unclear 2 [3]
Lacidipine metabolite M3 DM002591
101623327
Unclear 2 [3]
Lacidipine metabolite M4 DM002590
101623330
Unclear 2 [3]
Lacidipine metabolite M5 DM002588
101623328
Unclear 3 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001396 Lacidipine Lacidipine metabolite M6 Unclear Unclear [3]
MR001397 Lacidipine Lacidipine metabolite M1 Unclear Unclear [3]
MR001392 Lacidipine metabolite M1 Lacidipine metabolite M2 Unclear Unclear [3]
MR001393 Lacidipine metabolite M1 Lacidipine metabolite M4 Unclear Unclear [3]
MR001394 Lacidipine metabolite M1 Lacidipine metabolite M3 Unclear Unclear [3]
MR001390 Lacidipine metabolite M6 Lacidipine metabolite M2 Unclear Unclear [3]
MR001391 Lacidipine metabolite M2 Lacidipine metabolite M5 Unclear Unclear [3]
MR001395 Lacidipine metabolite M4 Lacidipine metabolite M5 Unclear Unclear [3]
⏷ Show the Full List of 8 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 ClinicalTrials.gov (NCT00328965) Lacidipine In Mild To Moderate Essential Hypertension Patients With Type 2 Diabetes In Korea.
2 The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects. Br J Clin Pharmacol. 2001 Feb;51(2):147-52.
3 Lacidipine metabolism in rat and dog: identification and synthesis of main metabolites Xenobiotica. 1992 Aug;22(8):899-916. doi: 10.3109/00498259209049897.

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