Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1010)
Drug Name
Medrogestone
Synonyms
Colpro; Colprone; Etogyn; MEDROGESTONE; Medrogesterone; Medrogeston; Medrogestona; Medrogestona [INN-Spanish]; Medrogestone (USAN/INN); Medrogestone [USAN:INN:BAN]; Medrogestonum; Medrogestonum [INN-Latin]; Metrogestone; Prothil; R 13615; SCHEMBL140614; 077DN93G5B; 6,17-Dimethyl-6-dehydroprogesterone; 6,17-Dimethylpregna-4,6-diene-3,20-dione; 6-Methyl-6-dehydro-17-methylprogesterone; 977-79-7; AY 13615S; AY-62022; BRN 2302887; EINECS 213-555-0; NSC 123018; NSC-123018; Pregna-4,6-diene-3,20-dione, 6,17-dimethyl-; UNII-077DN93G5B
Indication Corpus luteum cyst [ICD11: GA18] Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 340.5 Topological Polar Surface Area 34.1
Heavy Atom Count 25 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
9949848
ChEBI ID
CHEBI:135446
CAS Number
977-79-7
Formula
C23H32O2
Canonical SMILES
CC1=CC2C(CCC3(C2CCC3(C)C(=O)C)C)C4(C1=CC(=O)CC4)C
InChI
1S/C23H32O2/c1-14-12-17-18(21(3)9-6-16(25)13-20(14)21)7-11-23(5)19(17)8-10-22(23,4)15(2)24/h12-13,17-19H,6-11H2,1-5H3/t17-,18+,19+,21-,22-,23+/m1/s1
InChIKey
HCFSGRMEEXUOSS-JXEXPEPMSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Oxidation - Hydrolyzationn 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005837 Medrogestone Unclear Oxidation - Hydrolyzationn Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Menopause: A Guide for Women and Those who Love Them. Edited by Winnifred Berg Cutler, Celso-Ramon Garcia.
2 Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo. Life Sci. 2003 Nov 7;73(25):3201-12.
3 DrugBank(Pharmacology-Metabolism):Medrogestone

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