Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1308)
Drug Name
Pizotifen
Synonyms
Pizotifan; Pizotifen; Pizotifen (INN); Pizotifen [INN]; Pizotifene; Pizotifene [INN-French]; Pizotifeno; Pizotifeno [INN-Spanish]; Pizotifenum; Pizotifenum [INN-Latin]; Pizotyline (USAN); Pizotyline [USAN]; Polomigran; Sandomigran; Sandomygran; 0BY8440V3N; 15574-96-6; 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine; BC 105; BC-105; BRN 0753534; C19H21NS; CHEBI:50212; EINECS 239-632-9; Litec; MFCD00864192; FIADGNVRKBPQEU-UHFFFAOYSA-N; PIZOTYLINE; UNII-0BY8440V3N
Indication Migraine [ICD11: 8A80] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 295.4 Topological Polar Surface Area 31.5
Heavy Atom Count 21 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
27400
PubChem SID
5010370 ; 7980344 ; 8169757 ; 10509182 ; 14751522 ; 24714723 ; 25623658 ; 26756535 ; 34669927 ; 47207192 ; 47291792 ; 47365864 ; 47662958 ; 48035805 ; 48185659 ; 48416449 ; 49699409 ; 50015996 ; 57310432 ; 75504446 ; 85209443 ; 85278783 ; 85787805 ; 85788911 ; 89503750 ; 92711291 ; 103223858 ; 104299887 ; 117404128 ; 118048642 ; 124892409 ; 124892410 ; 125324589 ; 125536630 ; 126631018 ; 126657449 ; 126667030 ; 127850175 ; 131342662 ; 131895591 ; 134224322 ; 134993421 ; 135650835 ; 135668219 ; 137009871 ; 142472728 ; 144205577 ; 162177650 ; 162224663 ; 163137347
ChEBI ID
CHEBI:50212
CAS Number
15574-96-6
TTD Drug ID
D06XZR
Formula
C19H21NS
Canonical SMILES
CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1
InChI
1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
InChIKey
FIADGNVRKBPQEU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Pizotifen glucuronide metabolite DM004813 N. A. Conjugation - N-glucuronidation 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005179 Pizotifen Pizotifen glucuronide metabolite Conjugation - N-glucuronidation UGT2B10 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME0205 Homo sapiens
UDB10_HUMAN
2.4.1.17
[2]
References
1 Pizotifen to prevent migraine headaches.
2 Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97.

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