Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1317)
Drug Name
HSDB-3165
Synonyms
D-Gluconic acid potassium salt; Potassium gluconate; D-Gluconic acid, potassium salt; Gluconic acid potassium salt; Gluconic acid, monopotassium salt; Gluconsan; Gluconsan K; Kalium Gluconate; Kalium-beta; Kaon elixir; Katorin; Monopotassium D-gluconate; Potalium; Potasoral; Potassium D-gluconate; Potassuril; Sirokal; 12H3K5QKN9; 299-27-4; D-Gluconic acid, monopotassium salt; EINECS 206-074-2; HSDB 3165; K-Iao; KOK; Kaon; MFCD00064211; UNII-12H3K5QKN9; potassium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
Indication Essential hypertension [ICD11: BA00] Phase 1/2 [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 234.25 Topological Polar Surface Area 141
Heavy Atom Count 14 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
16760467
ChEBI ID
CHEBI:32032
CAS Number
299-27-4
Formula
C6H11KO7
Canonical SMILES
C(C(C(C(C(C(=O)[O-])O)O)O)O)O.[K+]
InChI
1S/C6H12O7.K/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h2-5,7-11H,1H2,(H,12,13);/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
InChIKey
HLCFGWHYROZGBI-JJKGCWMISA-M
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006130 HSDB-3165 Unclear Unclear FXYD2 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Sodium/potassium-transporting ATPase gamma (FXYD2) DME0206 Homo sapiens
ATNG_HUMAN
3.6.1.-
[2]
References
1 ClinicalTrials.gov (NCT03563573) Single-dose Potassium Supplementation in Patients With ADHD for Whom the Anesthetic Lidocaine is Ineffective.
2 Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8.

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