Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1363)
Drug Name
Propiverine
Synonyms
Pollarine; Propiverine HCl; Propiverine Hydrochlorride; Propiverine hydrochloride (JP17); Mictonetten; Mictonorm; Mictonorm (TN); SCHEMBL1034248; propiverin hydrochloride; propiverine hydrochloride; propiverine-hydrochloride; (1-methylpiperidin-4-yl) 2,2-diphenyl-2-propoxyacetate hydrochloride; 54556-98-8; AC1L9B4A; C23H29NO3.HCl; CAS-54556-98-8; CHEBI:8494; CHEMBL2359059; DSSTox_CID_26847; DSSTox_GSID_46847; DSSTox_RID_81957; DTXSID1046847; NCGC00181103-01; UNII-DC4GZD10H3; Bup-4 (TN); DC4GZD10H3; KFUJMHHNLGCTIJ-UHFFFAOYSA-N
Indication Overactive bladder [ICD11: GC50] Phase 4 [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 403.9 Topological Polar Surface Area 38.8
Heavy Atom Count 28 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
441412
ChEBI ID
CHEBI:8494
CAS Number
60569-19-9
TTD Drug ID
D0TV9K
Formula
C23H30ClNO3
Canonical SMILES
CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C.Cl
InChI
1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H
InChIKey
KFUJMHHNLGCTIJ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Omega-1-OH-Pr-BA(L) DM004830 N. A. Unclear 1 [4]
Omega-OH-P-4 DM004832 N. A. Unclear 1 [4]
P-4 (N-oxide) DM007049 N. A. Unclear 1 [3]
Propiverine DM-P-4 DM004825
11559429
Unclear 1 [5]
Propiverine metabolite DPr-P-4 DM004828
77157
Unclear 1 [4]
DPr-P-4 (N-oxide) DM007050 N. A. Unclear 2 [3]
Omega-1-OH-Pr-BA DM004831 N. A. Unclear 2 [4]
Omega-COOH-P-4 DM004833 N. A. Unclear 2 [4]
Omega-OH-DM-P-4 DM004826 N. A. Unclear 2 [5]
Propiverine metabolite DPr-P-4 (N-oxide) DM004829 N. A. Unclear 2 [4]
Benzilic acid DM004827
6463
Unclear 3 [4]
Benzilic acid DM004827
6463
Unclear 3 [3]
Benzilic acid DM004827
6463
Unclear 3 [5]
⏷ Show the Full List of 13  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005191 Propiverine Propiverine DM-P-4 Unclear Unclear [5]
MR005194 Propiverine P-4 (N-oxide) Unclear CYP3A4 ... [3]
MR005197 Propiverine Propiverine metabolite DPr-P-4 Unclear Unclear [4]
MR005200 Propiverine Omega-1-OH-Pr-BA(L) Unclear Unclear [4]
MR005203 Propiverine Omega-OH-P-4 Unclear Unclear [4]
MR005201 Omega-1-OH-Pr-BA(L) Omega-1-OH-Pr-BA Unclear Unclear [4]
MR005204 Omega-OH-P-4 Omega-COOH-P-4 Unclear Unclear [4]
MR005195 P-4 (N-oxide) DPr-P-4 (N-oxide) Unclear Unclear [3]
MR005192 Propiverine DM-P-4 Omega-OH-DM-P-4 Unclear Unclear [5]
MR005198 Propiverine metabolite DPr-P-4 Propiverine metabolite DPr-P-4 (N-oxide) Unclear Unclear [4]
MR005196 DPr-P-4 (N-oxide) Benzilic acid Unclear Unclear [3]
MR005202 Omega-1-OH-Pr-BA Benzilic acid Unclear Unclear [4]
MR005193 Omega-OH-DM-P-4 Benzilic acid Unclear Unclear [5]
MR005199 Unclear Benzilic acid Unclear Unclear [4]
⏷ Show the Full List of 14 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Dimethylaniline oxidase 1 (FMO1) DME0059 Homo sapiens
FMO1_HUMAN
1.14.13.8
[3]
Dimethylaniline oxidase 3 (FMO3) DME0039 Homo sapiens
FMO3_HUMAN
1.14.13.8
[3]
References
1 ClinicalTrials.gov (NCT00903045) Urinary Urgency Outcomes Following Propiverine Treatment for an Overactive Bladder.
2 Product monograph: Mictoryl (Propiverine hydrochloride modified-release capsules).
3 The muscarinic receptor antagonist propiverine exhibits (1)-adrenoceptor antagonism in human prostate and porcine trigonum
4 Pharmacokinetic Studies on Propiverine Hydrochloride
5 DrugBank(Pharmacology-Metabolism):Propiverine

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