Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1422)
Drug Name	Rifaximin
Synonyms	Cefuzonam sodium; Cosmosin; LS-150033; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-((1,2,3-thiadiazol-5-ylthio)methyl)-, sodium salt, (6R-(6-alpha,7-beta(Z)))-; AN-12160; CL 251931 sodium salt; DTXSID40231634; SCHEMBL11146524
Indication	Hepatic encephalopathy [ICD11: DB99]			Approved	[1]
Structure
Structure	3D MOL is unavailable		2D MOL
Pharmaceutical Properties	Molecular Weight	535.6	Topological Polar Surface Area		283
	Heavy Atom Count	33	Rotatable Bond Count		8
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count		14
Cross-matching ID	PubChem CID 23663402 CAS Number 82219-81-6 TTD Drug ID D04ITO Formula C16H14N7NaO5S4 Canonical SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CSC4=CN=NS4)C(=O)[O-].[Na+] InChI 1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1 InChIKey BCMSQWPLFBUUKW-MMDWUFFASA-M

The Metabolic Roadmap of This Drug

The Full List of Drug Metabolites (DM) of This Drug

DM Name	DM ID	PubChem ID	Reaction	DM Level	REF
Unclear	DM009999	N. A.	Unclear	1	[2]

The Full List of Metabolic Reaction (MR) of This Drug

MR ID	Reactant	Product	MR Type	DME	REF
MR013474	Rifaximin	Unclear	Unclear	CYP3A4	[2]

Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug

DME Name	DME Info	Species	Uniprot ID	EC Number	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Homo sapiens	CP3A4_HUMAN	1.14.14.55	[2]

References
1	Rifaximin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2	U. S. FDA Label -Rifaximin

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.