Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1468)
Drug Name
Selenious acid
Synonyms
Monohydrated selenium dioxide; SELENIOUS ACID; Selenious acid (H2SeO3); Selenious acid (USP); Selenious acid [USP]; Selenious acid, 98%; Selenite (SeO32-); Selenite ion(2-); Selenium dioxide, monohydrated; Selenous acid; Selenous acid, 98%; dihydroxidooxidoselenium; selenige Saeure; selenige Saure; 7783-00-8; AC1L1APE; CCRIS 5530; CHEBI:26642; DSSTox_CID_4300; EINECS 231-974-7; F6A27P4Q4R; HSDB 6065; MFCD00011331; Selenium, Reference Standard Solution; UNII-F6A27P4Q4R; selenious acid,selenous acid,monohydrated selenium dioxide
Indication Discovery agent Investigative [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 128.99 Topological Polar Surface Area 57.5
Heavy Atom Count 4 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
1091
ChEBI ID
CHEBI:26642
CAS Number
7783-00-8
Formula
H2O3Se
Canonical SMILES
O[Se](=O)O
InChI
1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)
InChIKey
MCAHWIHFGHIESP-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
H2Se DM005923
533
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006370 Selenious acid H2Se Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Thioredoxin reductase TR1 (TXNRD1) DME0210 Homo sapiens
TRXR1_HUMAN
1.8.1.9
[2]
References
1 Chemical stability of selenious acid in total parenteral nutrition solutions containing ascorbic acid. JPEN J Parenter Enteral Nutr. 1989 Mar-Apr;13(2):185-8.
2 Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
3 DrugBank(Pharmacology-Metabolism):Selenious acid

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.