Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1807)
Drug Name
LY-2811376
Synonyms
J-501480; LY 2811376; LY-2811376; LY2811376; MJQMRGWYPNIERM-HNNXBMFYSA-N; UR18YJ97SJ; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; (4s)-4-[2,4-Difluoro-5-(Pyrimidin-5-Yl)phenyl]-4-Methyl-5,6-Dihydro-4h-1,3-Thiazin-2-Amine; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; 1194044-20-6; 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-; CHEMBL2333941; UNII-UR18YJ97SJ
Indication Alzheimer disease [ICD11: 8A20] Phase 1 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 320.4 Topological Polar Surface Area 89.5
Heavy Atom Count 22 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
44251605
PubChem SID
85286240 ; 89983742 ; 99437206 ; 103924885 ; 137986191 ; 140419282 ; 144116165 ; 144236995 ; 160828708 ; 162011703 ; 162205125 ; 163093680 ; 163390266 ; 163620704 ; 163686021 ; 163842305 ; 164135005 ; 164193941 ; 172086121 ; 174006688 ; 174526511 ; 178103518 ; 184816523 ; 188899592 ; 204429761 ; 223378259 ; 223621253 ; 223705125 ; 224326043 ; 227634630 ; 242586937 ; 247529799 ; 249730473 ; 249807610 ; 249855753 ; 250200952 ; 251910650 ; 251963140 ; 252069907 ; 252109923 ; 252160837 ; 252444081 ; 252451578
CAS Number
1194044-20-6
TTD Drug ID
D0N1BF
Formula
C15H14F2N4S
Canonical SMILES
CC1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
InChI
1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
InChIKey
MJQMRGWYPNIERM-HNNXBMFYSA-N
References
1 ClinicalTrials.gov (NCT00838084) A Safety Study of LY2811376 Single Doses in Healthy Subjects.

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