Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1922)
Drug Name
D-Serine
Synonyms
D-2-Amino-3-hydroxypropanoic acid; D-2-Amino-3-hydroxypropionic Acid; MTCFGRXMJLQNBG-UWTATZPHSA-N; Serine D-form; Serine, D-; d-(+)-serine; serine d-; (2R)-2-amino-3-hydroxy-propanoic acid; (2R)-2-amino-3-hydroxypropanoic acid; (2R)-serine; (R)-2-Amino-3-hydroxypropionic acid; (R)-2-amino-3-hydroxypropanoic acid; (R)-Serine; 1K77H2Z9B1; 312-84-5; AI3-18476; CHEBI:16523; CHEMBL285123; D-Ser; D-Serin; D-Serine, 98%; D-serine; DSN; EINECS 206-229-4; MFCD00004269; NCGC00094363-03; NSC 77689; NSC77689; UNII-1K77H2Z9B1; [3h]-d-serine
Indication Parkinsonism [ICD11: 8A00] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 105.09 Topological Polar Surface Area 83.6
Heavy Atom Count 7 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
71077
PubChem SID
4003 ; 588250 ; 626975 ; 829388 ; 839068 ; 7887195 ; 8143525 ; 8194408 ; 14747454 ; 15146420 ; 17405644 ; 24278008 ; 26718244 ; 26753645 ; 26753646 ; 43127470 ; 46392862 ; 46508200 ; 47811035 ; 47885661 ; 48110736 ; 49748509 ; 49846980 ; 50045910 ; 50096464 ; 50096469 ; 50106988 ; 50106989 ; 53778194 ; 56312452 ; 56313140 ; 56437651 ; 57318000 ; 80530258 ; 85756772 ; 87350321 ; 87575662 ; 87636300 ; 90341480 ; 92298581 ; 92303181 ; 92717308 ; 99213597 ; 99224311 ; 103060962 ; 103204181 ; 103822437 ; 104038215 ; 104349603 ; 117518385
ChEBI ID
CHEBI:16523
CAS Number
312-84-5
TTD Drug ID
D02UDJ
Formula
C3H7NO3
Canonical SMILES
C(C(C(=O)O)N)O
InChI
1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKey
MTCFGRXMJLQNBG-UWTATZPHSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Imino-serine DM006602
129823688
Oxidation - Oxidationn 1 [3] , [4]
OH-pyruvate DM006603
964
Hydrolysis - Hydrolysis 2 [3] , [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007123 D-Serine Imino-serine Oxidation - Oxidationn DAO [3], [4]
MR007124 Imino-serine OH-pyruvate Hydrolysis - Hydrolysis Non-ME [3], [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
D-amino-acid oxidase (DAO) DME0565 Homo sapiens
OXDA_HUMAN
1.4.3.3
[2]
Nonenzymatical (Non-ME) DMEN081 . Not Available Not Available [3] , [4]
Serine racemase (SRR) DME0588 Homo sapiens
SRR_HUMAN
5.1.1.18
[3]
References
1 ClinicalTrials.gov (NCT00215904) D-serine Adjuvant Treatment for Parkinson's Disease.
2 Focus on the role of D-serine and D-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS). Front Mol Biosci. 2018 Feb 13;5:8.
3 D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.
4 D-Serine metabolism: new insights into the modulation of D-amino acid oxidase activity

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