Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2055)
Drug Name
Lactate
Synonyms
Acidum sarcolacticum; Espiritin; Fleischmilchsaeure; L(+)-LACTIC ACID; L-(+)-Lactic acid; L-(+)-alpha-Hydroxypropionic acid; L-Lactic acid; L-lactate; Lactic acid, L-; Paralactic acid; Paramilchsaeure; Propanoic acid, 2-hydroxy-, (2S)-; Sarcolactic acid; Tisulac; (+)-Lactic acid; (2S)-2-hydroxypropanoic acid; (S)-(+)-Lactic acid; (S)-2-Hydroxypropanoic acid; (S)-2-Hydroxypropionic acid; (S)-2-Hydroxypropionsaeure; (S)-Lactic acid; (S)-Milchsaeure; (S)-lactate; 79-33-4; PH 90; PLLA; PURAC; UNII-F9S9FFU82N
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 90.08 Topological Polar Surface Area 57.5
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
107689
PubChem SID
3486 ; 584014 ; 584016 ; 587061 ; 830465 ; 3133728 ; 7888600 ; 8145829 ; 10234386 ; 15119658 ; 15296943 ; 22387985 ; 22394324 ; 24851901 ; 24856738 ; 24870591 ; 24896289 ; 24896436 ; 44436662 ; 49747913 ; 49747914 ; 49988471 ; 51026137 ; 56435506 ; 56465040 ; 57338185 ; 57647809 ; 57648269 ; 85098642 ; 85098644 ; 85098646 ; 85165024 ; 87572116 ; 91614149 ; 92297919 ; 103304458 ; 103827554 ; 104379492 ; 117393789 ; 117541770 ; 126523065 ; 126596858 ; 128334453 ; 135019588 ; 135064941 ; 135651506 ; 136023815 ; 137008366 ; 142375398 ; 144080980
ChEBI ID
CHEBI:422
CAS Number
10326-41-7
TTD Drug ID
D06FZS
Formula
C3H6O3
Canonical SMILES
CC(C(=O)O)O
InChI
1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
InChIKey
JVTAAEKCZFNVCJ-REOHCLBHSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005363 Lactate Unclear Unclear LDHC [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Lactate dehydrogenase C (LDHC) DME0503 Homo sapiens
LDHC_HUMAN
1.1.1.27
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Lactate dehydrogenase C (LDHC) DME0503 Km = 10.73 microM
LDHC_HUMAN
[2]
References
1 The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. Nucleic Acids Res. 2020 Jan 8;48(D1):D1006-D1021. (Ligand id: 2932).
2 Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int. 2015 Feb 15;15:19.

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