Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2095)
Drug Name
GDP-l-fucose
Synonyms
GDP-L-fucose; GDP-fucose; Gdp fucose; guanosine diphosphate fucose; (6-deoxy-beta-l-galactopyranosyl) ester; AC1L96W5; CHEBI:17009; GTPL4578; [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy-[(3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyphosphoryl] hydrogen phosphate; guanosine 5'-[3-(6-deoxy-L-galactopyranosyl) dihydrogen diphosphate]
Indication Discovery agent Investigative [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 589.3 Topological Polar Surface Area 307
Heavy Atom Count 38 Rotatable Bond Count 8
Hydrogen Bond Donor Count 9 Hydrogen Bond Acceptor Count 17
Cross-matching ID
PubChem CID
135412609
ChEBI ID
CHEBI:17009
CAS Number
15839-70-0
Formula
C16H25N5O15P2
Canonical SMILES
CC1C(C(C(C(O1)OP(=O)(O)OP(=O)(O)OCC2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)O)O)O)O
InChI
1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1
InChIKey
LQEBEXMHBLQMDB-QIXZNPMTSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Colanic acid DM005896
9548797
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006328 GDP-l-fucose Colanic acid Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Fucosyltransferase X (FUT10) DME0528 Homo sapiens
FUT10_HUMAN
2.4.1.65
[2]
Fucosyltransferase XI (FUT11) DME0527 Homo sapiens
FUT11_HUMAN
2.4.1.152
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Fucosyltransferase X (FUT10) DME0528 Km = 0.013 microM
FUT10_HUMAN
[2]
Fucosyltransferase XI (FUT11) DME0527 Km = 0.013 microM
FUT11_HUMAN
[2]
References
1 G-SRS database: GUANOSINE 5'-DIPHOSPHO-.BETA.-L-FUCOSE
2 Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). J Biol Chem. 2009 Feb 13;284(7):4723-38.
3 Combinatorial Modular Pathway Engineering for Guanosine 5'-Diphosphate-l-fucose Production in Recombinant Escherichia coli

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