Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2153)
Drug Name
Phloroglucinol
Synonyms
Floroglucin; Benzene, 1,3,5-trihydroxy-; Benzene, trihydroxy; Benzene-1,3,5-triol; Benzene-s-triol; Dilospan S; Floroglucin [Czech]; Floroglucinol; Floroglucinol [Czech]; Phloroglucin; Phloroglucine; Phloroglucinol anhydrous; Spasfon-Lyoc; phloroglucinol; s-Trihydroxybenzene; sym-Trihydroxybenzene; 1,3,5-THB; 1,3,5-Trihydroxycyclohexatriene; 1,3,5-Triol; 1,3,5-benzenetriol; 1,3,5-trihydroxybenzene; 108-73-6; 3,5-Dihydroxyphenol; 5-Benzenetriol; 5-Hydroxyresorcinol; 5-Oxyresorcinol; 5-Oxyresorcinolphloroglucin; NSC 157; UNII-DHD7FFG6YS
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 126.11 Topological Polar Surface Area 60.7
Heavy Atom Count 9 Rotatable Bond Count 0
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
359
ChEBI ID
CHEBI:16204
CAS Number
108-73-6
TTD Drug ID
D07EXH
Formula
C6H6O3
Canonical SMILES
C1=C(C=C(C=C1O)O)O
InChI
1S/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H
InChIKey
QCDYQQDYXPDABM-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Phloroglucinol reductase (PHGR) DME1165 Eubacterium oxidoreducens
PHGR_EUBOX
1.3.1.57
[2]
References
1 Determination of phloroglucinol by HPLC-MS/MS and its application to a bioequivalence study in healthy volunteers. Eur Rev Med Pharmacol Sci. 2017 Apr;21(8):1990-1998.
2 Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41. J Biol Chem. 1989 Mar 15;264(8):4423-7.

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