Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2298)
Drug Name
Ofloxacin
Synonyms
Ocuflox; Ocuflox (TN); Oflocee; Oflocet; Oflocin; Oflodal; Oflodex; Oflodura; Ofloxacin (JP15/USP/INN); Ofloxacin Otic; Ofloxacin [USAN:BAN:INN:JAN]; Ofloxacin, (S)-Isomer; Ofloxacina; Ofloxacina [DCIT]; Ofloxacine; Ofloxacine [French]; Ofloxacino; Ofloxacino [Spanish]; Ofloxacinum; Ofloxacinum [Latin]; Ofloxin; Onexacin; Operan; Orocin; Otonil; Oxaldin; Pharflox; Praxin; Puiritol; Qinolon; Quinolon; Quotavil; Ru-43280; Sinflo; Tabrin; Taravid; Tariflox; Bactocin; DEXTROFLOXACINE; DL 8280; DL-8280; Danoflox; Effexin; Exocin; Exocine; FLOXIN IN DEXTROSE 5%; Flobacin; Flodemex; Flotavid; Flovid; Floxal; Floxil; Floxin; Floxin Otic (TN); Floxin otic; Floxstat; Fugacin; Inoflox; Kinflocin; Kinoxacin; Liflox; Loxinter; Marfloxacin; Marfloxacin (TN); Medofloxine; Mergexin; Novecin; Nufafloqo; O 8757; O-Flox; ORF 18489; ORF-28489; Occidal; Tarivid; Telbit; Tructum; Uro Tarivid; Viotisone; Visiren; WP-0405; Zanocin; (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (+/-)-Floxin; (-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure; 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin; FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; HOE 280; HOE-280; Hoe-280; OFLX; OFX; Obide; Ofcin; Oflin; Oflox; Ofus; PT 01; Qipro; Rilox; XED
Indication Pneumocystis pneumonia [ICD11: CA40] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 361.4 Topological Polar Surface Area 73.3
Heavy Atom Count 26 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8
Cross-matching ID
PubChem CID
4583
PubChem SID
9529 ; 597127 ; 3206370 ; 5025346 ; 7847519 ; 7891126 ; 7980182 ; 8027636 ; 8149812 ; 8152815 ; 11335896 ; 11361135 ; 11364080 ; 11366642 ; 11369204 ; 11372716 ; 11373806 ; 11377366 ; 11462107 ; 11466265 ; 11467385 ; 11485123 ; 11485970 ; 11489280 ; 11491314 ; 11492139 ; 11495000 ; 11533038 ; 12013736 ; 14876840 ; 17405462 ; 24278613 ; 24860450 ; 26612280 ; 26680409 ; 26747609 ; 26747610 ; 26747611 ; 26747612 ; 29223672 ; 46507574 ; 47216794 ; 47291150 ; 47515336 ; 47589018 ; 47589019 ; 47959764 ; 48035139 ; 48259249 ; 48259250
ChEBI ID
CHEBI:7731
CAS Number
82419-36-1
TTD Drug ID
D03NHW
Formula
C18H20FN3O4
Canonical SMILES
CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
InChI
1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChIKey
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Desmethyl ofloxacin DM002276
133905
Unclear 1 [3]
Ofloxacin N-oxide metabolite DM002277
10362217
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002927 Ofloxacin Desmethyl ofloxacin Unclear Unclear [3]
MR002928 Ofloxacin Ofloxacin N-oxide metabolite Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1279 Methanobrevibacter oralis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1280 Methanobrevibacter smithii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1281 Methanomassiliicoccus luminyensis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1282 Methanosphaera stadtmanae Not Available Not Available [2]
References
1 Ofloxacin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J Antimicrob Chemother. 2011 Sep;66(9):2038-44.
3 The pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide in haemodialysis patients with end-stage renal failure J Antimicrob Chemother. 1988 Sep;22 Suppl C:65-72. doi: 10.1093/jac/22.supplement_c.65.

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