Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2323)
Drug Name
Mannitol
Synonyms
Mannazucker; Mannidex; Mannidex 16700; Mannigen; Mannistol; Mannit; Mannite; Mannitol (USP); Mannitol (VAN); Mannitol 10%; Mannitol 10% In Plastic Container; Mannitol 15%; Mannitol 15% In Plastic Container; Mannitol 20%; Mannitol 20% In Plastic Container; Mannitol 5%; Mannitol 5% In Plastic Container; Mannitol [USAN]; Mannogem 2080; Marine Crystal; Osmitrol; Osmitrol (TN); Osmitrol 10% In Water; Osmitrol 15% In Water; Osmitrol 20% In Water; Osmitrol 5% In Water; Cordycepic acid; D-(-)-Mannitol; D-Mannitol (JP15); D-mannite; D-mannitol; DL-Mannitol; Diosmol; Hexahydroxyhexane; Invenex; Isotol; MANNITOL 25%; Manita; Maniton-S; Manna sugar; Osmofundin; Osmosal; Resectisol; Resectisol In Plastic Container; SDM No. 35; Sorbitol-Mannitol; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol; (L)-Mannitol; Cpd without stereochemical designation; ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D; M0044; MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER; MANNITOL 15% DEXTROSE 5% IN SODIUM CHLORIDE 0.45%; MANNITOL 5% DEXTROSE 5% IN SODIUM CHLORIDE 0.12%; MTL; OSMITROL 10% IN WATER IN PLASTIC CONTAINER; OSMITROL 15% IN WATER IN PLASTIC CONTAINER; OSMITROL 20% IN WATER IN PLASTIC CONTAINER; OSMITROL 5% IN WATER IN PLASTIC CONTAINER; SORBITOL-MANNITOL IN PLASTIC CONTAINER
Indication Cerebral oedema [ICD11: 8D60] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 182.17 Topological Polar Surface Area 121
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
6251
PubChem SID
2928 ; 3682 ; 829269 ; 831961 ; 831967 ; 7847130 ; 7889067 ; 8025969 ; 8025992 ; 8145744 ; 8153931 ; 11528330 ; 12088020 ; 15195196 ; 16045072 ; 22435040 ; 24779011 ; 24860225 ; 24882727 ; 24882728 ; 24882729 ; 24896586 ; 24896902 ; 24897257 ; 24897341 ; 24897346 ; 26757663 ; 29225247 ; 46499979 ; 46506446 ; 48413961 ; 48416194 ; 48416764 ; 48423215 ; 49830006 ; 49990266 ; 53789262 ; 56310769 ; 56310961 ; 56311311 ; 56311364 ; 56311415 ; 56313258 ; 56320903 ; 56322640 ; 57323291 ; 57647519 ; 57648837 ; 57651947 ; 57651948
ChEBI ID
ChEBI:16899
CAS Number
69-65-8
TTD Drug ID
D0P7EK
Formula
C6H14O6
Canonical SMILES
C(C(C(C(C(CO)O)O)O)O)O
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChIKey
FBPFZTCFMRRESA-KVTDHHQDSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Fructose DM005524
2723872
Unclear 1 [3]
Glycogen DM006465
439177
Unclear 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006949 Mannitol Glycogen Unclear Unclear [4]
MR006950 Mannitol D-Fructose Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [2]
References
1 Mannitol was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
3 Peripherally inserted central catheters--use in home care
4 Long-term results of resection of the distal ulna for post-traumatic conditions

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