Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2416)
Drug Name
D-lactic acid
Synonyms D-lactate; R-lactic acid
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 90.08 Topological Polar Surface Area 57.5
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
61503
PubChem SID
3555 ; 584618 ; 830897 ; 841761 ; 7887063 ; 8187556 ; 15119659 ; 17422462 ; 24277150 ; 24877806 ; 24889912 ; 24890061 ; 24890158 ; 24896259 ; 24898218 ; 26697263 ; 26750213 ; 43118764 ; 46504203 ; 46505582 ; 46505962 ; 51026136 ; 57314410 ; 57653568 ; 57653643 ; 57653681 ; 85165074 ; 85285983 ; 91699006 ; 102851572 ; 103383632 ; 104179373 ; 104323513 ; 124954527 ; 125003340 ; 125003346 ; 126523953 ; 126674611 ; 127318856 ; 127318857 ; 128334456 ; 132628374 ; 135017738 ; 135651476 ; 137002793 ; 140074716 ; 143491644 ; 144211160 ; 152222664 ; 152239946
ChEBI ID
CHEBI:42111
CAS Number
79-33-4
TTD Drug ID
D0DA9T
Formula
C3H6O3
Canonical SMILES
CC(C(=O)O)O
InChI
1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
InChIKey
JVTAAEKCZFNVCJ-UWTATZPHSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
CO2 DM000908
280
Oxidation - Oxidationn 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004185 D-lactic acid Carbon dioxide Oxidation - Oxidationn Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Lactate racemase (Lsa784) DME1198 Lactobacillus sakei
Q3BCH3_LACSK
5.1.2.1
[2]
References
1 PubChem 2019 update: improved access to chemical data. Nucleic Acids Res. 2019 Jan 8; 47(D1):D1102-1109. (PubChem CID: 61503)
2 The effect of sodium acetate on the growth yield, the production of L- and D-lactic acid, and the activity of some enzymes of the glycolytic pathway of Lactobacillus sakei NRIC 1071(T) and Lactobacillus plantarum NRIC 1067(T). J Gen Appl Microbiol. 2002 Apr;48(2):91-102.
3 [D(-)Lactic acid--a metabolism problem]

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