Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2426)
Drug Name
Prontosil
Synonyms
Aseptil rojo (TN); Prontosil rubrum; Q64Q9N6Q6O; Rubiazol; SCHEMBL155098; SCHEMBL155099; Sulfamidochrysoidine; TX-017879; ob sie prontosil; prontosil; 103-12-8; 4-[(2,4-diaminophenyl)diazenyl]benzenesulfonamide; AI3-09088; Benzenesulfonamide, 4-((2,4-diaminophenyl)azo)-; CHEBI:8464; CHEMBL488279; CTK4A1757; DTXSID60145608; EINECS 203-081-2; P-[(2,4-diaminophenyl)azo]benzenesulphonamide; UNII-Q64Q9N6Q6O; p-((2,4-Diaminophenyl)azo)benzenesulphonamide; p-[(2,4-Diaminophenyl)azo]benzenesulfonamide
Indication Pseudomonas infection [ICD11: 1G40] Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 291.33 Topological Polar Surface Area 145
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
66895
ChEBI ID
CHEBI:8464
CAS Number
103-12-8
Formula
C12H13N5O2S
Canonical SMILES
C1=CC(=CC=C1N=NC2=C(C=C(C=C2)N)N)S(=O)(=O)N
InChI
1S/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)
InChIKey
ABBQGOCHXSPKHJ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Prontosil N-glucuronide DM006986 N. A. Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007608 Prontosil Prontosil N-glucuronide Unclear Unclear [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Azoreductase (azoR) DME1476 Streptococcus pyogenes
A0A074IU04_STRSL
1.7.1.6
[2]
References
1 Prontosil related terms.
2 Intestinal azo-reduction and glucuronide conjugation of prontosil. Xenobiotica. 1973 Sep;3(9):599-604.

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