| General Information of Drug (ID:
DR3188) |
| Drug Name |
OT-551
|
| Synonyms |
Tempol-H prodrug, Othera |
| Indication |
Glaucoma
[ICD11: 9C61]
|
Phase 2
|
[1]
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| Structure |
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3D MOL
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2D MOL
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| Pharmaceutical Properties |
Molecular Weight |
241.33 |
Topological Polar Surface Area |
49.8 |
| Heavy Atom Count |
17 |
Rotatable Bond Count |
3 |
| Hydrogen Bond Donor Count |
1 |
Hydrogen Bond Acceptor Count |
4 |
| Cross-matching ID |
- PubChem CID
- 10131000
- CAS Number
-
- TTD Drug ID
- D0P1IX
- Formula
- C13H23NO3
- Canonical SMILES
- CC1(CC(CC(N1O)(C)C)OC(=O)C2CC2)C
- InChI
- InChI=1S/C13H23NO3/c1-12(2)7-10(8-13(3,4)14(12)16)17-11(15)9-5-6-9/h9-10,16H,5-8H2,1-4H3
- InChIKey
- ZWEXEKJLDHNLLA-UHFFFAOYSA-N
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| The Metabolic Roadmap of This Drug |
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| The Full List of Drug Metabolites (DM) of This Drug |
| DM Name |
DM ID |
PubChem ID |
Reaction |
DM Level |
REF |
|
TEMPOL-H
|
DM014879
|
|
Unclear
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Unclear |
1 |
[2]
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| The Full List of Metabolic Reaction (MR) of This Drug |
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| References |
| 1 |
ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health.
|
| 2 |
Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats
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