Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5147)
Drug Name
Methazolamide
Synonyms Methazolamide (oral, sustained release)
Indication Glaucoma [ICD11: 9C61] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 236.3 Topological Polar Surface Area 139
Heavy Atom Count 14 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
4100
ChEBI ID
CHEBI:6822
CAS Number
554-57-4
TTD Drug ID
D0C2II
Formula
C5H8N4O3S2
Canonical SMILES
CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
InChI
InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)
InChIKey
FLOSMHQXBMRNHR-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Methazolamide M1 DM018825 N. A. Unclear - Unclear 1 [2]
MSO DM016303
71312806
Unclear - Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR011182 Methazolamide Methazolamide M1 Unclear - Unclear CYP [2]
MR011183 Methazolamide M1 MSO Unclear - Unclear Unclear [2]
References
1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6828).
2 The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

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