Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5168)
Drug Name
Phenmetrazine
Synonyms
Cafilon; Defenmetrazin; Dexphenmetrazine; Fenmetrazin; Fenmetrazina; Oxazimedrine; Phenmetraline; Phenmetrazin; Phenmetrazinum; Preludin hydrochloride; A 66; Psychamine A 66; Defenmetrazin (TN); Fenmetrazin (TN); Fenmetrazina [INN-Spanish]; Oxazimedrine (TN); Phenmetraline (TN); Phenmetrazine [INN:BAN]; Phenmetrazinum [INN-Latin]; Dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine; 2-Fenyl-3-methylmorfolin; 2-Fenyl-3-methylmorfolin [Czech]; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
Indication Obesity [ICD11: 5B80-5B81] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 177.24 Topological Polar Surface Area 21.3
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4762
ChEBI ID
CHEBI:8067
CAS Number
134-49-6
TTD Drug ID
D0M2MC
Formula
C11H15NO
Canonical SMILES
CC1C(OCCN1)C2=CC=CC=C2
InChI
InChI=1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3
InChIKey
OOBHFESNSZDWIU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
3-oxophenmetrazine DM014990
21789
Other reaction - Lactam formation 1 [3]
4'-Hydroxyphenmetrazine DM015247
191340
Oxidation - Aromatic Hydroxylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010869 Phenmetrazine 3-oxophenmetrazine Other reaction - Lactam formation Unclear [3]
MR010870 Phenmetrazine 4'-Hydroxyphenmetrazine Oxidation - Aromatic Hydroxylation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A (CYP3A) DMEN065 . Not Available Not Available [2]
References
1 Drug information of Phenmetrazine, 2008. eduDrugs.
2 DrugBank(Pharmacology-Metabolism):Phenmetrazine
3 Comparative metabolism of the amphetamine drugs of dependence in man and monkeys

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.