Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5351)
Drug Name
Angiotensin Ii
Synonyms
Human angiotensin II; Angiotensin II human; 4474-91-3; Angiotensin II (mouse); Angiotensin II (human); Giapreza; Ang II; 5-Isoleucine-angiotensin II; 5-L-Isoleucineangiotensin II; Ile(5)-angiotensin II; 1-8-Angiotensin I; isoleucine(5)-angiotensin II;Angiotensin II, human; Isoleucine5-angiotensin II; Angiotensin II, ile(5)-; Angiotensin ii [INN:JAN]
Indication Increase blood pressure [ICD11: BA04] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 1046.2 Topological Polar Surface Area 409
Heavy Atom Count 75 Rotatable Bond Count 29
Hydrogen Bond Donor Count 13 Hydrogen Bond Acceptor Count 15
Cross-matching ID
PubChem CID
172198
ChEBI ID
CHEBI:2719
CAS Number
4474-91-3
TTD Drug ID
D0G6SE
Formula
C50H71N13O12
Canonical SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChI
InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChIKey
CZGUSIXMZVURDU-JZXHSEFVSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Angiotensin 1-7 DM015144
123805
Hydrolysis - Hydrolysis 1 [3]
Angiotensin III DM015405
3082042
Other reaction - Degradation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR008061 Angiotensin Ii Angiotensin 1-7 Hydrolysis - Hydrolysis ACE2 ... [3]
MR008062 Angiotensin Ii Angiotensin III Other reaction - Degradation ACE [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Angiotensin-converting enzyme 2 (ACE2) DME0446 Homo sapiens
ACE2_HUMAN
3.4.17.23
[2]
Angiotensin-converting enzyme 2 (ACE2) DME0446 Homo sapiens
ACE2_HUMAN
3.4.17.23
[3]
Glutamyl aminopeptidase (ENPEP) DMEN744 Homo sapiens
AMPE_HUMAN
3.4.11.7
[3]
Lysosomal Pro-X carboxypeptidase (PRCP) DMEN745 Homo sapiens
PCP_HUMAN
3.4.16.2
[4]
References
1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2 FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice
3 DrugBank(Pharmacology-Metabolism):Angiotensin Ii
4 Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II

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