Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5898)
Drug Name	Mitapivat
Synonyms	Mitapivat\|PKR-IN-1\|1260075-17-9\|AG-348\|2WTV10SIKH\|n-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide\|N-[4-[4-(cyclopropylmethyl)piperazine-1-carbonyl]phenyl]quinoline-8-sulfonamide\|8-Quinolinesulfonamide, N-(4-((4-(cyclopropylmethyl)-1-piperazinyl)carbonyl)phenyl)-\|N-(4-((4-(Cyclopropylmethyl)-1-piperazinyl)carbonyl)phenyl)-8-quinolinesulfonamide\|PKM2 activator 1020\|MITAPIVAT [INN]\|UNII-2WTV10SIKH\|MITAPIVAT [WHO-DD]\|SCHEMBL2702716\|CHEMBL4299940\|GTPL10473\|AG348\|BCP19727\|EX-A2626\|BDBM50597714\|s6508\|PKR-IN-1; PKM2 activator 1020\|AT10134\|CS-3895\|NCGC00386704-01\|NCGC00386704-02\|AC-36187\|compound 80a [WO2011002817A1]\|HY-12689\|MS-28179\|PKR-IN-1; PKM2 activator 1020; PKM2 activator;AG348;AG-348;AG 348
Pharmaceutical Properties	Molecular Weight	450.6	Topological Polar Surface Area	91
	Heavy Atom Count	32	Rotatable Bond Count	6
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	6
Cross-matching ID	PubChem CID 59634741 Formula C24H26N4O3S Canonical SMILES C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5 InChI InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2 InChIKey XAYGBKHKBBXDAK-UHFFFAOYSA-N

The Metabolic Roadmap of This Drug

The Full List of Drug Metabolites (DM) of This Drug

DM Name	DM ID	PubChem ID	Reaction	DM Level	REF
Unclear	DM009999	N. A.	Unclear	1	[1]

The Full List of Metabolic Reaction (MR) of This Drug

MR ID	Reactant	Product	MR Type	DME	REF
MR005538	Mitapivat	Unclear	Unclear	CYP3A4	[1]

Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug

DME Name	DME Info	Species	Uniprot ID	EC Number	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Homo sapiens	CP3A4_HUMAN	1.14.14.55	[1]

References
1	DrugBank(Pharmacology-Metabolism):Mitapivat

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.