Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0004)
Drug Name
INS-339(II)
Synonyms
Acetest; Natriumphosphat; Dibasic sodium phosphate; Disodium acid orthophosphate; Disodium acid phosphate; Disodium hydrogen phosphate; Disodium hydrogenorthophosphate; Disodium hydrophosphate; DISODIUM PHOSPHATE; Disodium monohydrogen phosphate; Disodium orthophosphate; Disodium phosphoric acid; Phosphate of soda; Phosphoric acid, disodium salt; Soda phosphate; Sodium hydrogen phosphate; Sodium hydrogenphosphate; Sodium monohydrogen phosphate; Sodium phosphate dibasic; sec-Sodium phosphate; 7558-79-4; Caswell No. 778; FEMA Number 2398
Indication Diabetes mellitus [ICD11: 5A10] Phase 1 [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 141.959 Topological Polar Surface Area 83.4
Heavy Atom Count 7 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
24203
ChEBI ID
CHEBI:34683
CAS Number
7558-79-4
TTD Drug ID
D0Q4VO
Formula
HNa2O4P
Canonical SMILES
OP(=O)([O-])[O-].[Na+].[Na+]
InChI
1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
InChIKey
BNIILDVGGAEEIG-UHFFFAOYSA-L
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Steroid 17-alpha-monooxygenase (CYP17A1) DME0024 Homo sapiens
CP17A_HUMAN
1.14.99.9
[2]
References
1 ClinicalTrials.gov (NCT00876655) Exploratory Pharmacokinetic and Bioavailability Study of 2 Capsule Formulations of Torezolid Phosphate.
2 Transcriptional complexes at the CYP17 CRS. Endocr Res. 2002 Nov;28(4):551-8.

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