Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0082)
Drug Name
Amcinonide
Synonyms
Amcinonido; Amcinonido [INN-Spanish]; Amcinonidum; Amcinonidum [INN-Latin]; Cyclocort; Cyclocort (TN); Triamcinolonacetatcyclopentanonid; Visderm; amcinonida; amcinonide; 19alpha-Fluor-11beta,21-dihydroxy-16alpha,17alpha-(tetramethylen)methylendioxy-1,4-pregnadien-3,20-dion 21-acetat; 423W026MA9; 51022-69-6; C28H35FO7; CHEBI:31199; CL 34699; CL-34699; EINECS 256-915-2; MLS000028656; MLS001333715; SMR000058920; UNII-423W026MA9
Indication Allergic contact dermatitis [ICD11: EK00 ] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 502.6 Topological Polar Surface Area 99.1
Heavy Atom Count 36 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 8
Cross-matching ID
PubChem CID
443958
PubChem SID
855515 ; 7848450 ; 7978681 ; 10299444 ; 15084976 ; 24890657 ; 36887100 ; 46506705 ; 50926096 ; 56352910 ; 56422434 ; 56423154 ; 57404572 ; 57653835 ; 71825482 ; 92712334 ; 93576974 ; 99368349 ; 103770715 ; 104631033 ; 124801285 ; 126625654 ; 126656779 ; 134338306 ; 135001553 ; 135653543 ; 136014083 ; 137005249 ; 138911215 ; 139999915 ; 144204964 ; 152100586 ; 160963636 ; 162198485 ; 175266120 ; 175612165 ; 178103639 ; 179116554 ; 226396660 ; 241090273 ; 250133950 ; 252401183
ChEBI ID
ChEBI:31199
CAS Number
51022-69-6
TTD Drug ID
D06XHC
Formula
C28H35FO7
Canonical SMILES
CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CCC5=CC(=O)C=CC54C)F)O)C)OC6(O2)CCCC6
InChI
1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1
InChIKey
ILKJAFIWWBXGDU-MOGDOJJUSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Amcinonide M1 PDM007077
21980959
Hydrolysis - Hydrolysis of carboxylic acid ester 1 Human
Amcinonide M2 PDM007078
76734599
Hydrolysis - Hydrolysis of carboxylic acid ester 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Amcinonide was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35.

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