Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0087)
Drug Name
Aminobutyric acid
Synonyms
Aminalon; Butyric acid, 4-amino-; Gaballon; Gamarex; Gamastan; Gammagee; Gammalon; Gammalone; Gammar; Gammasol; Gamulin; Immu-G; Mielogen; Mielomade; Piperidic acid; Piperidinic acid; Reanal; butanoic acid, 4-amino-; gamma-Amino butyric acid; gamma-Aminobutanoic acid; gamma-Aminobuttersaeure; gamma-amino-n-butyric acid; gamma-aminobutyric acid; omega-Aminobutyric acid; .gamma.-Aminobutyric acid; 3-Carboxypropylamine; 4-Aminobutanoic acid; 4-amino-butanoic acid; 4-aminobutanoate; 4-aminobutyrate; 4-aminobutyric acid; GABA
Indication Epilepsy [ICD11: 8A60] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 103.12 Topological Polar Surface Area 63.3
Heavy Atom Count 7 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
119
PubChem SID
3628 ; 87901 ; 90737 ; 99151 ; 102735 ; 588080 ; 841798 ; 3131894 ; 5006226 ; 7847126 ; 7885654 ; 7979337 ; 8138105 ; 8138144 ; 8138251 ; 8138279 ; 8139983 ; 8145275 ; 8149630 ; 8150467 ; 10527343 ; 11110722 ; 11113457 ; 11335791 ; 11361030 ; 11362843 ; 11365405 ; 11367967 ; 11372289 ; 11374436 ; 11376129 ; 11462002 ; 11484732 ; 11489024 ; 11491200 ; 11492624 ; 11493863 ; 14818111 ; 17404570 ; 24278167 ; 24424261 ; 24424263 ; 24438498 ; 24701168 ; 24715057 ; 24891025 ; 25623205 ; 26512225 ; 26612021 ; 26679211
ChEBI ID
ChEBI:16865
CAS Number
56-12-2
TTD Drug ID
D0C9XA
Formula
C4H9NO2
Canonical SMILES
C(CC(=O)O)CN
InChI
1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChIKey
BTCSSZJGUNDROE-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 ClinicalTrials.gov (NCT04144439) Effect of GABA on ADHD and Seizures in Children With Epilepsy..
2 Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology. 2004 Feb;145(2):699-705.

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