Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0088)
Drug Name
Aminolevulinic acid
Synonyms
Aladerm; Ameluz; Aminolevulinate; Aminolevulinic acid; Kerastick; Levulinic acid, 5-amino-; Pentanoic acid, 5-amino-4-oxo-; ZGXJTSGNIOSYLO-UHFFFAOYSA-N; delta-ALA; delta-aminolevulinic acid; 106-60-5; 4-oxo-5-amino-pentanoic acid; 5-ALA; 5-Amino-4-oxopentanoate; 5-Amino-4-oxopentanoic acid; 5-Amino-4-oxovaleric acid; 5-Aminolevulinate; 5-Aminolevulinic acid; 5-amino-4-oxo-pentanoic acid; 5-amino-levulinate; 5-amino-levulinic acid; 88755TAZ87; CCRIS 8958; CHEBI:17549; CHEMBL601; DALA; EINECS 203-414-1; UNII-88755TAZ87
Indication Anogenital warts [ICD11: 1A95] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 131.13 Topological Polar Surface Area 80.4
Heavy Atom Count 9 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
137
PubChem SID
3719 ; 841472 ; 5427092 ; 8144107 ; 8150474 ; 11342129 ; 11362312 ; 11364476 ; 11367038 ; 11369600 ; 11372726 ; 11374315 ; 11377762 ; 11485579 ; 11487714 ; 11489478 ; 11491469 ; 11492433 ; 11495396 ; 15170674 ; 24438516 ; 46506856 ; 47589325 ; 47662632 ; 50002793 ; 50122683 ; 51031867 ; 51091887 ; 53789366 ; 56320695 ; 56322917 ; 57319985 ; 85083671 ; 85291378 ; 92298402 ; 92712186 ; 93166418 ; 99451455 ; 103182993 ; 104098261 ; 104170099 ; 104293958 ; 108134724 ; 118693344 ; 121362447 ; 124799829 ; 125662954 ; 126523837 ; 126579879 ; 126630164
ChEBI ID
ChEBI:17549
CAS Number
106-60-5
TTD Drug ID
D0Y7ZD
Formula
C5H9NO3
Canonical SMILES
C(CC(=O)O)C(=O)CN
InChI
1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
InChIKey
ZGXJTSGNIOSYLO-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Aminolevulinic acid M1 PDM007092
1021
Other reaction - Hydration/dehydration of C-O bond 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Porphobilinogen synthase (ALAD) DME0401 Homo sapiens
HEM2_HUMAN
4.2.1.24
[2]
References
1 Aminolevulinic Acid was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Modifying effects of delta-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity. Toxicol Lett. 2018 Oct 1;295:351-356.

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