Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0330)
Drug Name
Ciprofibrate
Synonyms
Ciprofibrate; Ciprofibrato; Ciprofibrato [INN-Spanish]; Ciprofibratum; Ciprofibratum [INN-Latin]; Lipanor; Modalim; WIN 35833; Win-35833; 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid; 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid; 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 52214-84-3; BRN 1984981; C13H14Cl2O3; CCRIS 173; CHEBI:50867; EINECS 257-744-6; Propanoic acid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-
Indication Hypertriglyceridaemia [ICD11: 5C80] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 289.15 Topological Polar Surface Area 46.5
Heavy Atom Count 18 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
2763
PubChem SID
4816527 ; 7978950 ; 8151784 ; 10852034 ; 11467104 ; 11468224 ; 11486732 ; 12013723 ; 14775650 ; 17397655 ; 17404731 ; 24278288 ; 26757866 ; 28325632 ; 29221918 ; 47291293 ; 47291294 ; 47365389 ; 47736670 ; 47959950 ; 48413469 ; 48415783 ; 49699279 ; 49857263 ; 50105908 ; 50105909 ; 50889815 ; 53777274 ; 53789241 ; 56311292 ; 56312796 ; 56312797 ; 56352999 ; 56463556 ; 57321443 ; 85175392 ; 85230953 ; 85788082 ; 90340632 ; 91011906 ; 92125998 ; 92303711 ; 92713293 ; 103689672 ; 103914561 ; 104301538 ; 117868533 ; 121360841 ; 121363669 ; 124749506
ChEBI ID
ChEBI:50867
CAS Number
52214-84-3
TTD Drug ID
D0EJ6O
Formula
C13H14Cl2O3
Canonical SMILES
CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl
InChI
1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
InChIKey
KPSRODZRAIWAKH-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Ciprofibrate M1 PDM007387 N. A. Conjugation - Glycine conjugation 1 Human
Ciprofibrate M2 PDM007388
71332839
Conjugation - O-Glucuronidation of aliphatic acid 1 Human
Ciprofibrate M3 PDM007389 N. A. Conjugation - Carnitine conjugation 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 ClinicalTrials.gov (NCT00350038) Irbesartan, Ciprofibrate and Their Combination Onto the Endothelial Functions.
2 Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62.

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