Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0360)
Drug Name
Clotiapine
Synonyms
Clothiapine; Clothiapine [USAN]; Clotiapina [INN-Spanish]; Clotiapine; Clotiapinum [INN-Latin]; Entumin; Entumine; Etumine; HF 2159; KAAZGXDPUNNEFN-UHFFFAOYSA-N; LW 2159; S-805C; Z05HCY0X1T; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine; 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine; 2058-52-8; BRN 0568276; C18H18ClN3S; CHEMBL304902; Dibenzo[b,f][1,4]thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-; EINECS 218-162-8; UNII-Z05HCY0X1T
Indication Schizophrenia [ICD11: 6A20] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 343.9 Topological Polar Surface Area 44.1
Heavy Atom Count 23 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
16351
ChEBI ID
CHEBI:31424
CAS Number
2058-52-8
TTD Drug ID
D0PX8L
Formula
C18H18ClN3S
Canonical SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=C(C=C4)Cl
InChI
1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
InChIKey
KAAZGXDPUNNEFN-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A7 (CYP3A7) DME0015 Homo sapiens
CP3A7_HUMAN
1.14.14.1
[2]
References
1 Clotiapine compared with chlorpromazine in chronic schizophrenia. Schizophr Res. 2005 Dec 15;80(2-3):343-7.
2 Biotransformation of post-clozapine antipsychotics: pharmacological implications. Clin Pharmacokinet. 2000 May;38(5):393-414.

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