Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0397)
Drug Name
Cysteamine
Synonyms
Comperlan MM; Loramine MY 228; Myristamide MEA; Myristic monoethanolamide; Myristoyl monoethanolamide; Myristoyl-EA; Myristoyl-ethanolamine; Myristyl monoethanolamide; N-(2-HYDROXYETHYL)TETRADECANAMIDE; N-(2-Hydroxyethyl)myristamide; N-(Tetradecanoyl)-ethanolamine; N-myristoylethanolamine; Schercomid MME; myristoyl ethanolamide; tetradecanoyl ethanolamide; 142-58-5; 6CYG57WXZ0; AC1Q5PMK; EINECS 205-546-5; HSDB 5640; Monoethanolamine myristic acid condensate; Tetradecanamide, N-(2-hydroxyethyl)-; UNII-6CYG57WXZ0
Indication Nephropathic cystinosis [ICD11: 5C60] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 271.44 Topological Polar Surface Area 49.3
Heavy Atom Count 19 Rotatable Bond Count 14
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
8890
PubChem SID
4871774 ; 8156317 ; 14775002 ; 29227526 ; 75282554 ; 85291988 ; 103832227 ; 104319009 ; 107223647 ; 117540185 ; 125719032 ; 126677373 ; 128275178 ; 134973230 ; 137250658 ; 162791510 ; 176326518 ; 178101906 ; 180112642 ; 198976125 ; 223659058 ; 226647802 ; 249807261
ChEBI ID
ChEBI:17141
CAS Number
60-23-1
TTD Drug ID
D0V0LB
Formula
C16H33NO2
Canonical SMILES
CCCCCCCCCCCCCC(=O)NCCO
InChI
1S/C16H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(19)17-14-15-18/h18H,2-15H2,1H3,(H,17,19)
InChIKey
JHIXEZNTXMFXEK-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Cystamine DM003759
2915
Unclear 1 [3]
Cysteamine cysteine mixed disulfide DM003760
424083
Unclear 2 [3]
Cysteamine DM003761
6058
Unclear 3 [3]
Thialysine DM003762
20049
Unclear 4 [3]
Keto Thialysine DM003763
71329502
Unclear 5 [3]
AECK DM003764
188242
Unclear 6 [3]
1,4-thiomorpholine-3-carboxylate DM003765
28125548
Unclear 7 [3]
ACEK-DD DM003766
6425567
Unclear 7 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012821 Cysteamine Cystamine Unclear Unclear [3]
MR012822 Cystamine Cysteamine cysteine mixed disulfide Unclear Unclear [3]
MR012823 Cysteamine cysteine mixed disulfide Cysteamine Unclear Unclear [3]
MR012824 Cysteamine Thialysine Unclear Unclear [3]
MR012825 Thialysine Keto Thialysine Unclear Unclear [3]
MR012826 Keto Thialysine AECK Unclear Unclear [3]
MR012827 AECK 1,4-thiomorpholine-3-carboxylate Unclear Unclear [3]
MR012828 AECK ACEK-DD Unclear Unclear [3]
⏷ Show the Full List of 8 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Myeloperoxidase (MPO) DME0096 Homo sapiens
PERM_HUMAN
1.11.2.2
[2]
References
1 Cysteamine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Thiols as peroxidase substrates. Free Radic Biol Med. 1993 Feb;14(2):167-75.
3 Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism

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