Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0957)
Drug Name
Lidoflazine
Synonyms
Lidoflazin; Lidoflazina [INN-Spanish]; Lidoflazina [Italian]; Lidoflazine [USAN:INN:BAN]; Lidoflazinum; Lidoflazinum [INN-Latin]; MCN-JR-7904; McN-JR 7904; Ordiflazine; R 7904; Clinium; Corflazine; J4ZHN3HBTE; Klinium; LIDOFLAZINE; 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-; 3416-26-0; 4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide; Angex; BRN 0904339; C30H35F2N3O; CAS-3416-26-0; CHEMBL92870; EINECS 222-312-8; NCGC00016627-01; NCGC00016627-04; UNII-J4ZHN3HBTE
Indication Cognitive impairment [ICD11: 6D71] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 491.6 Topological Polar Surface Area 35.6
Heavy Atom Count 36 Rotatable Bond Count 9
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
3926
ChEBI ID
CHEBI:93095
CAS Number
3416-26-0
TTD Drug ID
D0L7VL
Formula
C30H35F2N3O
Canonical SMILES
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI
1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
InChIKey
ZBIAKUMOEKILTF-UHFFFAOYSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000236)
2 Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17.

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