Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1049)
Drug Name
Methoxyphenamine
Synonyms
Euspirol; METHOXYPHENAMINE; Methamphetamine, 2-methoxy; Methoxifenaminio; Methoxiphenadrin; Methoxiphenadrinum; Methoxyphenadrine; Methoxyphenamin; Methoxyphenamine [INN:BAN]; Methoxyphenaminum; Methoxyphenaminum [INN-Latin]; Metossifenamina [DCIT]; Metoxifenaminio [INN-Spanish]; Orthoxine; Ortodrinex; Ortoxine; Oxalacetic acid orthoxine; Proasma; 2-Methoxy-N,alpha-dimethylphenethylamin; 2-Methoxy-N-methylamphetamine; 2-Methoxymethamphetamine; 93-30-1; Asmi; EINECS 202-237-7; o-Methoxy-N,alpha-dimethylphenethylamine
Indication Chronic obstructive pulmonary disease [ICD11: CA22] Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 179.26 Topological Polar Surface Area 21.3
Heavy Atom Count 13 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4117
ChEBI ID
CHEBI:134817
CAS Number
93-30-1
Formula
C11H17NO
Canonical SMILES
CC(CC1=CC=CC=C1OC)NC
InChI
1S/C11H17NO/c1-9(12-2)8-10-6-4-5-7-11(10)13-3/h4-7,9,12H,8H2,1-3H3
InChIKey
OEHAYUOVELTAPG-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
5-Hydroxy-Methoxyphenamine DM003890 N. A. Unclear 1 [3]
N-Desmethyl-Methoxyphenamine DM003888
159755
Unclear 1 [3]
O-Desmethyl-Methoxyphenamine DM003889 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012879 Methoxyphenamine N-Desmethyl-Methoxyphenamine Unclear CYP [3]
MR012880 Methoxyphenamine O-Desmethyl-Methoxyphenamine Unclear CYP [3]
MR012881 Methoxyphenamine 5-Hydroxy-Methoxyphenamine Unclear CYP [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 Index Nominum 2000: International Drug Directory. Page: 670.
2 Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations. Xenobiotica. 1995 Sep;25(9):895-906.
3 Kinetics of in vitro metabolism of methoxyphenamine in rats

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