Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1065)
Drug Name
Methyprylon
Synonyms
Methprylon; Methyprolon; Methyprylon [INN]; Methyprylone; Methyprylone [INN-French]; Methyprylonum; Methyprylonum [INN-Latin]; Metiprilon; Metiprilona; Metiprilona [INN-Spanish]; Metiprilone; Noctan; Nodular; Noludar; Ro 1-6463; Dimerin; methyprylon; 125-64-4; 2,4-Dioxo-3,3-diethyl-5-methylpiperidine; 2,4-Dioxy-3,3-diethyl-5-methylpiperidine; 3,3-Diethyl-2,4-dioxo-5-methylpiperidine; 3,3-Diethyl-5-methyl-2,4-piperidinedione; 3,3-Diethyl-5-methylpiperidine-2,4-dione; DEA No. 2575; NSC 30442
Indication Insomnia [ICD11: 7A00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 183.25 Topological Polar Surface Area 46.2
Heavy Atom Count 13 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4162
PubChem SID
89654 ; 5336447 ; 7848213 ; 8152604 ; 10506099 ; 15195213 ; 29223268 ; 46506891 ; 48416265 ; 50016188 ; 51047044 ; 57322168 ; 103770773 ; 104305608 ; 129239503 ; 132522176 ; 134337972 ; 134973035 ; 137089235 ; 137260976 ; 160964441 ; 178103812 ; 179225913 ; 226520013 ; 250037516
ChEBI ID
CHEBI:31837
CAS Number
125-64-4
TTD Drug ID
D05OQJ
Formula
C10H17NO2
Canonical SMILES
CCC1(C(=O)C(CNC1=O)C)CC
InChI
1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)
InChIKey
SIDLZWOQUZRBRU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Methyprylon Metabolite (5-methylpyrithyldione) DM004373
68842
Unclear 1 [3] , [4] , [5]
Methyprylon Metabolite DM004374
89269
Unclear 2 [3]
Methyprylon Metabolite DM004375
165444432
Unclear 3 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004702 Methyprylon Methyprylon Metabolite (5-methylpyrithyldione) Unclear Unclear [3], [4], [5]
MR004703 Methyprylon Metabolite (5-methylpyrithyldione) Methyprylon Metabolite Unclear Unclear [3]
MR004704 Methyprylon Metabolite Methyprylon Metabolite Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 Methyprylon was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Drugs and steatohepatitis. Semin Liver Dis. 2002;22(2):185-94.
3 The determination of methyprylon and its metabolites in biological fluids by gas chromatography
4 Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration
5 Determination of methyprylon and its dehydro metabolite, 5-methylpyrithyldione, in plasma by high-performance liquid chromatography

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