Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1203)
Drug Name
FT-0710230
Synonyms
Meconic acid; Mekonsaure; NSC 805; NSC-805; NSC805; Opium acid; Poppy acid; Q421116; SCHEMBL546968; SCHEMBL600257; UNII-V502I79516; V502I79516; ZEGRKMXCOCRTCS-UHFFFAOYSA-N; ZINC1587602; Opio; Papaver somniferum exudate; Papaver somniferum resin; 3-HYDROXY-4-OXO-4H-PYRAN-2,6-DICARBOXYLIC ACID; 3-Hydroxy-4-oxo-1,4-pyran-2,6-dicarboxylic acid; 3-Hydroxy-4-oxopyran-2,6-dicarboxylic acid; 3-hydroxy-4-oxo-pyran-2,6-dicarboxylic acid; 3-hydroxy-4-pyrone-2,6-dicarboxylic acid; 497-59-6; 4H-Pyran-2, 3-hydroxy-4-oxo-; 4H-Pyran-2,6-dicarboxylic acid, 3-hydroxy-4-oxo-; 4H-Pyran-2,6-dicarboxylicacid, 3-hydroxy-4-oxo-; BDBM50147502; C20209; CHEMBL109516; CTK1D7773; DB-083476; DTXSID2060096; EINECS 207-848-2
Indication Opiate dependence [ICD11: 6C43] Phase 3 [1]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
10347
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
FT-0710230 M1 PDM007990 N. A. Reduction - Reduction of carbonyl 1 Human
FT-0710230 M2 PDM007991 N. A. Conjugation - Glycine conjugation 1 Human
FT-0710230 M3 PDM007992 N. A. Conjugation - Glycine conjugation 1 Human
FT-0710230 M4 PDM007993 N. A. Conjugation - O-Glucuronidation of aliphatic acid 1 Human
FT-0710230 M5 PDM007994 N. A. Conjugation - O-Glucuronidation of aliphatic acid 1 Human
FT-0710230 M6 PDM007995 N. A. Conjugation - Carnitine conjugation 1 Human
FT-0710230 M7 PDM007996 N. A. Conjugation - Carnitine conjugation 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 ClinicalTrials.gov (NCT02502175) Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder.
2 Interpretation of opiate urine drug screens.

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