Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1240)
Drug Name
Paramethasone
Synonyms
Parametasona; Parametasona [INN-Spanish]; Parametasone; Parametasone [DCIT]; Paramethasone [INN:BAN]; Paramethasonum; Paramethasonum [INN-Latin]; Paramezone; VFC6ZX3584; paramethasone; 16alpha-Methyl-6alpha-fluoroprednisolone; 53-33-8; Cassenne; Cortiden; Dillar; Flumethone; Metilar; 6alpha-Fluoro-16alpha-methylprednisolone; CHEBI:7922; CS 1483; EINECS 200-169-2; HSDB 3376; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-; UNII-VFC6ZX3584
Indication Allergy [ICD11: 4A80] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 392.5 Topological Polar Surface Area 94.8
Heavy Atom Count 28 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5875
PubChem SID
9617 ; 7980251 ; 8153630 ; 14805315 ; 29224902 ; 46504651 ; 48416380 ; 50064864 ; 50465193 ; 57323008 ; 96024431 ; 103589742 ; 104310501 ; 126665814 ; 127307276 ; 134222135 ; 134337718 ; 134971016 ; 136062799 ; 137005255 ; 160964662 ; 179316245 ; 184548300 ; 198940543 ; 223440592 ; 223672701 ; 226396369 ; 241093244
ChEBI ID
ChEBI:7922
CAS Number
53-33-8
TTD Drug ID
D03IKT
Formula
C22H29FO5
Canonical SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F
InChI
1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
InChIKey
MKPDWECBUAZOHP-AFYJWTTESA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Paramethasone metabolite M1 DM001176 N. A. Oxidation - Hydroxylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001947 Paramethasone Paramethasone metabolite M1 Oxidation - Hydroxylation CYP3A4 [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Paramethasone was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35.
3 Metabolism of systematically given corticosteroids Dermatologica. 1975;151(3):129-34. doi: 10.1159/000251325.

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