Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1273)
Drug Name
Phenformin
Synonyms
Phenethyldiguanide; Phenformine; Phenformine [INN-French]; Phenforminum; Phenforminum [INN-Latin]; Phenformix; Phenylethylbiguanide; Azucaps; Cronoformin; Db-retard; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenformina [INN-Spanish]; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; N-Phenethylbiguanide; Normoglucina; PHENFORMIN; Retardo; beta-PEBG; beta-Phenethylbiguanide; 1-Phenethylbiguanide; 114-86-3; D Bretard; DB Comb; N-(2-Phenylethyl)imidodicarbonimidic diamide; Pedg
Indication Diabetes mellitus [ICD11: 5A10] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 205.26 Topological Polar Surface Area 103
Heavy Atom Count 15 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
8249
PubChem SID
9875 ; 615911 ; 4583360 ; 10504499 ; 11112448 ; 11364804 ; 11367366 ; 11369928 ; 11372968 ; 11375528 ; 11378095 ; 11466207 ; 11467327 ; 11485734 ; 14773187 ; 29226965 ; 46505230 ; 47217161 ; 47736859 ; 47811132 ; 47960115 ; 47960116 ; 48416408 ; 49698378 ; 49854764 ; 50100445 ; 57288470 ; 57324876 ; 78063341 ; 85787916 ; 88835501 ; 94569120 ; 96025038 ; 99452969 ; 103426218 ; 104098499 ; 104317320 ; 117524452 ; 117879477 ; 124882390 ; 124882391 ; 124882392 ; 125325517 ; 125823034 ; 126687817 ; 128146967 ; 131850042 ; 134223094 ; 134337521 ; 134974542
ChEBI ID
CHEBI:8064
CAS Number
114-86-3
TTD Drug ID
D07XPE
Formula
C10H15N5
Canonical SMILES
C1=CC=C(C=C1)CCN=C(N)N=C(N)N
InChI
1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
InChIKey
ICFJFFQQTFMIBG-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
4-Hydroxyphenformin DM004794
10013772
Oxidation - Hydrolyzationn 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005154 Phenformin 4-Hydroxyphenformin Oxidation - Hydrolyzationn Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 Drug information of Phenformin, 2008. eduDrugs.
2 Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Mol Pharmacol. 1991 Jul;40(1):63-8.
3 DrugBank(Pharmacology-Metabolism):Phenformin

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