| General Information of Drug (ID:
DR1311) |
| Drug Name |
FCU-2711
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| Synonyms |
Polatuzumab Vedotin; ACD-79B-VCMMAE; ACD-79BVCMMAE; ACD79B-VCMMAE; DCDS-4501A; FCU-2711; Polatuzumab vedotin-piiq; RG-7596; RG7596; RO-5541077-000; RO-5541077000; CHEMBL3301582 |
| Indication |
Diffuse large B-cell lymphoma
[ICD11: 2A81]
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Phase 3
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[]
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| Cross-matching ID |
- PubChem CID
- 223370409
- TTD Drug ID
- D05QOL
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| The Metabolic Roadmap of This Drug |
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| The Full List of Drug Metabolites (DM) of This Drug |
| DM Name |
DM ID |
PubChem ID |
Reaction |
DM Level |
REF |
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MMAE
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DM003185
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Unclear |
1 |
[2]
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FCU-2711 Metabolite M3
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DM003189
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N. A. |
Unclear |
2 |
[2]
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FCU-2711 Metabolite M4
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DM003190
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N. A. |
Unclear |
2 |
[2]
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FCU-2711 Metabolite M6
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DM003186
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N. A. |
Unclear |
2 |
[2]
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FCU-2711 Metabolite M1
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DM003191
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N. A. |
Unclear |
3 |
[2]
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FCU-2711 Metabolite M2
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DM003188
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N. A. |
Unclear |
3 |
[2]
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FCU-2711 Metabolite M5
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DM003187
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N. A. |
Unclear |
3 |
[2]
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FCU-2711 Metabolite M2
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DM003188
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N. A. |
Unclear |
4 |
[2]
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| The Full List of Metabolic Reaction (MR) of This Drug |
| ⏷ Show the Full List of 8 MR(s)
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| Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug |
| DME Name |
DME Info |
Species |
Uniprot ID |
EC Number |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
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DME0001
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Homo sapiens
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[1]
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| References |
| 1 |
FDA label of Polatuzumab vedotin-piiq. The 2020 official website of the U.S. Food and Drug Administration.
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| 2 |
Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY(?)) Antibody-Drug Conjugate in Sprague Dawley Rats
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