Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1318)
Drug Name
Practolol
Synonyms
Practololo [DCIT]; Practololum; Practololum [INN-Latin]; Praktololu; Praktololu [Polish]; Teranol; dl-Practolol; practolol; rac Practolol; Dalzic; Eraldin; Eralzdin Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide; 6673-35-4; AY 21011; CCRIS 1089; ICI 50172; ICI-50172; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide; N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE; N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
Indication Cardiac arrhythmia [ICD11: BC65] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 266.34 Topological Polar Surface Area 70.6
Heavy Atom Count 19 Rotatable Bond Count 7
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
4883
PubChem SID
13861 ; 4500647 ; 7979385 ; 8150016 ; 8153002 ; 10321694 ; 11336076 ; 11361315 ; 11364348 ; 11366910 ; 11369472 ; 11374635 ; 11377634 ; 11462287 ; 11466360 ; 11467480 ; 11485240 ; 11486020 ; 11489388 ; 11492674 ; 11495268 ; 15197223 ; 26679880 ; 26751910 ; 26980600 ; 29223962 ; 46507496 ; 47207250 ; 47440331 ; 47959823 ; 48185058 ; 48259303 ; 48334570 ; 48334571 ; 48334572 ; 48414361 ; 49698824 ; 49860734 ; 50104588 ; 56413037 ; 56463034 ; 57322502 ; 80701653 ; 85209244 ; 85451356 ; 85788851 ; 87660772 ; 92125329 ; 92308845 ; 99301989
ChEBI ID
CHEBI:258351
CAS Number
6673-35-4
TTD Drug ID
D0KD1U
Formula
C14H22N2O3
Canonical SMILES
CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O
InChI
1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
InChIKey
DURULFYMVIFBIR-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
3-hydroxypractolol DM004815
192960
Oxidation - Hydrolyzationn 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005181 Practolol 3-hydroxypractolol Oxidation - Hydrolyzationn Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 Central Drugs Standard Control Organization.
2 Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432.
3 Practolol: aspects of its metabolism and ocular binding in the hamster

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