Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1608)
Drug Name
Tocopherol
Synonyms Methyltocols; tocoferol; tocoferoles; tocophrol; Tocopherols
Indication Phenylketonuria [ICD11: 5C50] Phase 2 [1]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
14985
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
13'-hydroxychromanol DM003619
45479210
Oxidation - Hydrolyzationn 1 [4]
13'-carboxychromanol DM003620
58003830
Oxidation - Oxidationn 2 [4]
CDMDHC DM003621
76043741
Oxidation - Oxidationn 3 [4]
CDMOHC DM003622
76043807
Oxidation - Oxidationn 4 [4]
CDMHHC DM003623
76043802
Oxidation - Oxidationn 5 [4]
CMBHC DM003624
45356845
Oxidation - Oxidationn 6 [4]
CEHC DM003625
9943542
Oxidation - Oxidationn 7 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004053 Tocopherol 13'-hydroxychromanol Oxidation - Hydrolyzationn CYP3A4 ... [4]
MR004054 13'-hydroxychromanol 13'-carboxychromanol Oxidation - Oxidationn Unclear [4]
MR004055 13'-carboxychromanol CDMDHC Oxidation - Oxidationn Unclear [4]
MR004056 CDMDHC CDMOHC Oxidation - Oxidationn Unclear [4]
MR004057 CDMOHC CDMHHC Oxidation - Oxidationn Unclear [4]
MR004058 CDMHHC CMBHC Oxidation - Oxidationn Unclear [4]
MR004059 CMBHC CEHC Oxidation - Oxidationn Unclear [4]
⏷ Show the Full List of 7 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Cytochrome P450 4F2 (CYP4F2) DME0025 Homo sapiens
CP4F2_HUMAN
1.14.13.30
[3]
Cytochrome P450 4F2 (CYP4F2) DME0025 Homo sapiens
CP4F2_HUMAN
1.14.13.30
[4]
References
1 ClinicalTrials.gov (NCT03797222) Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome.
2 A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels. Atherosclerosis. 2007 Jul;193(1):229-33.
3 Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci. 2004 Dec;1031:13-21.
4 Complexity of vitamin E metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.