Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1908)
Drug Name
PR-934423
Synonyms
PR 1032-644; PR 934-423; PR-934-423; PR1032-646; REMACEMIDE; Remacemida; Remacemida [INN-Spanish]; Remacemide [INN]; Remacemidum; Remacemidum [INN-Latin]; (+)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (+-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; 128298-28-2; 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide; Acetamide, 2-amino-N-(1-methyl-1,2-diphenylethyl)-, (+)-; FPL 12924; FPL 14144; FPL 14145; FPL-12944AA
Indication Anaesthesia [ICD11: 8E22] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 268.35 Topological Polar Surface Area 55.1
Heavy Atom Count 20 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
60511
PubChem SID
6257068 ; 8186897 ; 14848312 ; 43117902 ; 49858030 ; 49858031 ; 49858032 ; 50787713 ; 57314025 ; 85788157 ; 90490603 ; 92729779 ; 103199491 ; 104320951 ; 125823975 ; 126682339 ; 129840666 ; 131297093 ; 135047599 ; 135203406 ; 135203407 ; 142472738 ; 173894588 ; 179080708 ; 179577889 ; 203098689 ; 223657235 ; 226516225 ; 249995109 ; 252770057
ChEBI ID
CHEBI:91654
CAS Number
128298-28-2
TTD Drug ID
D05JET
Formula
C17H20N2O
Canonical SMILES
CC(CC1=CC=CC=C1)(C2=CC=CC=C2)NC(=O)CN
InChI
1S/C17H20N2O/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14/h2-11H,12-13,18H2,1H3,(H,19,20)
InChIKey
YSGASDXSLKIKOD-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
6-Hydroxyrebamipide DM005937
13471531
Oxidation - Oxidationn 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006410 PR-934423 Desglycinyl-remacemide Oxidation - Oxidationn CYP3A4 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J Pharmacol Exp Ther. 1996 Jan;276(1):161-8.
2 Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Res. 2002 May;49(3):247-54.

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