Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1932)
Drug Name
Fructose
Synonyms
Apir Levulosa; D(-)-Fructose; D(-)-Fructose, 99%; D-(-)-Fructose; D-(-)-Fructose, >=99%; D-(-)-Levulose; D-Levulose; DL-Fructose; Fructon; Fructose solution; Fructose, D-; Fructose, pure; Furucton; Hi-Fructo 970; Levulosa; Levulosa Baxter; Levulosa Braun; Levulosa Ibys; Levulosa Ife; Levulosa Mein; Levulosado Braun; Methose; Nevulose; Sugar, fruit; arabino-Hexulose; keto-D-fructose; (3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one; 30237-26-4; 53188-23-1; 57-48-7; AI3-23514; CCRIS 3335; EINECS 200-333-3; Krystar 300; MFCD00148910
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 118
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5984
PubChem SID
13089 ; 7847182 ; 8153720 ; 14716675 ; 15339912 ; 16877774 ; 29204153 ; 29225000 ; 46491008 ; 46530493 ; 49970811 ; 57323096 ; 68530625 ; 75359324 ; 92298678 ; 103822107 ; 104225898 ; 104310785 ; 117559373 ; 117613538 ; 123120957 ; 124759816 ; 127301939 ; 127301940 ; 127301941 ; 127301942 ; 127301943 ; 127301944 ; 127301945 ; 127301946 ; 127301947 ; 127301948 ; 127301949 ; 127301950 ; 127301951 ; 127301952 ; 127301953 ; 127301954 ; 127301955 ; 127301956 ; 127301957 ; 127301958 ; 127301959 ; 127301960 ; 127301961 ; 127301962 ; 127301963 ; 127301964 ; 127301965 ; 127301966
ChEBI ID
CHEBI:48095
CAS Number
57-48-7
TTD Drug ID
D06HZY
Formula
C6H12O6
Canonical SMILES
C(C(C(C(C(=O)CO)O)O)O)O
InChI
1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5-,6-/m1/s1
InChIKey
BJHIKXHVCXFQLS-UYFOZJQFSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
FFAs DM005891 N. A. Unclear 1 [4]
Lactate DM003259
91435
Unclear 1 [4]
Uric acid DM000021
1175
Unclear 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006316 Fructose Uric acid Unclear Unclear [4]
MR006317 Fructose FFAs Unclear Unclear [4]
MR006318 Fructose Lactate Unclear Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Sorbitol dehydrogenase (SORD) DME0578 Homo sapiens
DHSO_HUMAN
1.1.1.14
[2]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [3]
References
1 Fructose and nonalcoholic fatty liver disease. J Calif Dent Assoc. 2016 Oct 13;44(10):613-17.
2 Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins. Protein Expr Purif. 2013 Nov;92(1):128-33.
3 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
4 High fructose diet: A risk factor for immune system dysregulation

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