Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2046)
Drug Name
Ferricyanide
Synonyms
Ferric hexacyanide; Ferricyanide; Hexacyanoferrate(III); Hexazyanoferrat(III); hexacyanidoferrate(3-); hexacyanidoferrate(III); hexacyanoferrate III; hexacyanoferrate(3-); hexacyanoiron(3-); 13408-62-3; CHEBI:5020; CRWNKXHVYMVLCY-UHFFFAOYSA-N; [Fe(CN)6](3-)
Indication Discovery agent Investigative [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 211.95 Topological Polar Surface Area 143
Heavy Atom Count 13 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 12
Cross-matching ID
PubChem CID
439210
ChEBI ID
CHEBI:5020
CAS Number
13408-62-3
Formula
C6FeN6-3
Canonical SMILES
[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[Fe+3]
InChI
1S/6CN.Fe/c6*1-2;/q6*-1;+3
InChIKey
YAGKRVSRTSUGEY-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Ferricyanide Metabolite A1 DM004157 N. A. Reduction - Reduction 1 [4]
Ferricyanide Metabolite A2 DM004158 N. A. Reduction - Reduction 1 [5]
Ferrocyanide DM004159
9552077
Reduction - Reduction 1 [6]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004560 Ferricyanide Ferricyanide Metabolite A1 Reduction - Reduction NDDH [4]
MR004561 Ferricyanide Ferricyanide Metabolite A2 Reduction - Reduction PDHX [5]
MR004562 Ferricyanide Ferrocyanide Reduction - Reduction Unclear [6]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Diaphorase-1 (CYB5R3) DME0473 Homo sapiens
NB5R3_HUMAN
1.6.2.2
[2]
Methionine synthase reductase (MTRR) DME0431 Homo sapiens
MTRR_HUMAN
1.16.1.8
[3]
NADH-dependent dehydrogenase (NDDH) DMEN216 Bacteroides fragilis Not Available Not Available [4]
Pyruvate dehydrogenase protein X component (PDHX) DMEN109 Homo sapiens
ODPX_HUMAN
Not Available [5]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Diaphorase-1 (CYB5R3) DME0473 Km = 0.006 microM
NB5R3_HUMAN
[2]
Methionine synthase reductase (MTRR) DME0431 Km = 0.663 microM
MTRR_HUMAN
[3]
References
1 Ferricyanide related terms.
2 Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding. Arch Biochem Biophys. 2006 Mar 1;447(1):59-67.
3 Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85.
4 Transmembrane ferricyanide reduction by cells of the yeast Saccharomyces cerevisiae
5 Reduction of ferricyanide by thiamine or thiamine pyrophosphate
6 13C-NMR studies of transmembrane electron transfer to extracellular ferricyanide in human erythrocytes

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