Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2089)
Drug Name
D-mannose-1-phosphate
Synonyms
D-Mannopyranose, 1-phosphate; D-Mannopyranose-1-phosphate; D-Mannose 1-phosphate; D-mannose 1-phosphates; D-mannose-1-phosphate; Mannose 1-phosphate; Mannose 1-phosphate-Mannopyranose; Mannose 1-phosphoric acid; SCHEMBL284741; alpha-delta-Mannose 1-phosphate; delta-mannose 1-phosphates; delta-mannose-1-phosphate; mannose-1-P; 1-(dihydrogen phosphate)-D-Mannopyranose; 27251-84-9; AC1LD8PO; CHEBI:35374; D-Mannose, 1-(dihydrogen phosphate); D-mannopyranose 1-(dihydrogen phosphate); DB02867; Epitope ID:145013
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.14 Topological Polar Surface Area 157
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
644175
PubChem SID
841804 ; 8707300 ; 14717793 ; 16035443 ; 43765895 ; 46508602 ; 50578002 ; 57408217 ; 92298108 ; 109827701 ; 126525672 ; 135108938 ; 137129299 ; 160966030 ; 175443086 ; 226628685 ; 241047475 ; 247382093
ChEBI ID
CHEBI:35374
CAS Number
27251-84-9
TTD Drug ID
D03AZI
Formula
C6H13O9P
Canonical SMILES
C(C1C(C(C(C(O1)OP(=O)(O)O)O)O)O)O
InChI
1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1
InChIKey
HXXFSFRBOHSIMQ-QTVWNMPRSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
GDP-mannose DM003833
135398627
Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004190 D-mannose-1-phosphate GDP-mannose Unclear PSA1 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Mannose-1-phosphate guanyltransferase (PSA1) DMEN153 Saccharomyces cerevisiae
MPG1_YEAST
2.7.7.13
[2]
Phosphomannomutase 1 (PMM1) DME0453 Homo sapiens
PMM1_HUMAN
5.4.2.8
[3]
Phosphomannomutase 2 (PMM2) DME0452 Homo sapiens
PMM2_HUMAN
5.4.2.8
[3]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Phosphomannomutase 1 (PMM1) DME0453 Km = 0.016 microM
PMM1_HUMAN
[3]
Phosphomannomutase 2 (PMM2) DME0452 Km = 0.016 microM
PMM2_HUMAN
[3]
References
1 How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Enhanced secretion of heterologous proteins in Kluyveromyces lactis by overexpression of the GDP-mannose pyrophosphorylase, KlPsa1p
3 The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26.

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