Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2121)
Drug Name
Phosphate
Synonyms
Phosphoric acid trianion; Phosphate ion; Phosphate ions; Phosphates; NBIIXXVUZAFLBC-UHFFFAOYSA-K; NK08V8K8HR; O-Phosphate; PO4(3-); orthophosphate; phosphate; phosphoric acid, ion(3-); tetraoxidophosphate(3-); tetraoxophosphate(3-); tetraoxophosphate(V); 14265-44-2; AC1L1AN2; AKOS015903596; BDBM50155537; CHEBI:18367; CTK0H5978; DTXSID7039672; I14-18227; MFCD00145108; PO4; UNII-NK08V8K8HR; [PO4](3-); a phosphate group
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 94.971 Topological Polar Surface Area 86.2
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
1061
PubChem SID
3071 ; 840917 ; 841057 ; 7728230 ; 7889982 ; 8144764 ; 8150953 ; 14709385 ; 15218698 ; 24439414 ; 53787703 ; 56310835 ; 56311388 ; 57320705 ; 79295108 ; 103066731 ; 103077071 ; 104042950 ; 104075345 ; 104296651 ; 125331104 ; 125823182 ; 126524047 ; 134989311 ; 135292823 ; 137001640 ; 142051012 ; 152043015 ; 163304750 ; 175268694 ; 176264609 ; 176270178 ; 223741247
ChEBI ID
CHEBI:18367
CAS Number
14265-44-2
TTD Drug ID
D08VYC
Formula
O4P-3
Canonical SMILES
[O-]P(=O)([O-])[O-]
InChI
1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
GDP-D-glucose phosphorylase 1 (GDPGP1) DME0469 Homo sapiens
GDPP1_HUMAN
2.7.7.78
[2]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
GDP-D-glucose phosphorylase 1 (GDPGP1) DME0469 Km = 2.9 microM
GDPP1_HUMAN
[]
References
1 The role of phosphate in kidney disease. Nat Rev Nephrol. 2017 Jan;13(1):27-38.
2 A Novel GDP-d-glucose Phosphorylase Involved in Quality Control of the Nucleoside Diphosphate Sugar Pool in Caenorhabditis elegans and Mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23.

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