Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2146)
Drug Name
Mannose
Synonyms
Carubinose; D(+)-Mannose; D-(+)-Mannose; D-Mannopyranose; D-Mannopyranoside; D-Mannose; D-Mannose,(S); DL-Mannose; Mannopyranose; Mannopyranose, D-; Mannopyranoside; Mannose; Seminose; WQZGKKKJIJFFOK-QTVWNMPRSA-N; (+-)-Mannose; (3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; 530-26-7; AC1L2D5C; CHEBI:4208; CHEMBL469448; D-Man; DTXSID5040463; EINECS 208-474-2; Epitope ID:152206; GTPL4650; MLS001332527; MLS001332528; Man; SCHEMBL38300; SMR000857125; alpha,beta-D-mannopyranose; bmse000018; bmse000874; bmse000882
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 110
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
18950
PubChem SID
3459 ; 824810 ; 838927 ; 3135279 ; 8027205 ; 8164149 ; 14720290 ; 15066909 ; 15322061 ; 22396012 ; 24277482 ; 24882738 ; 24882739 ; 24896601 ; 24897068 ; 26737907 ; 29217866 ; 29286577 ; 53788969 ; 56311267 ; 56320690 ; 56323500 ; 56475044 ; 57330235 ; 57651949 ; 79376412 ; 85164870 ; 87572161 ; 91700886 ; 92298697 ; 92710545 ; 93375117 ; 103583168 ; 104346557 ; 124801461 ; 125310805 ; 126523054 ; 126631771 ; 127844171 ; 129621449 ; 131317572 ; 131465283 ; 134228441 ; 134228449 ; 134958993 ; 134984714 ; 134999617 ; 135136220 ; 137002180 ; 139416018
ChEBI ID
CHEBI:4208
CAS Number
530-26-7
TTD Drug ID
D0GS9E
Formula
C6H12O6
Canonical SMILES
C(C1C(C(C(C(O1)O)O)O)O)O
InChI
1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6?/m1/s1
InChIKey
WQZGKKKJIJFFOK-QTVWNMPRSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Mannose-6-phosphate DM005492
65127
Unclear 1 [1]
Unclear DM009999 N. A. Unclear 1 [1]
Unclear DM009999 N. A. Unclear 2 [1]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005851 Mannose Mannose-6-phosphate Unclear HK [1]
MR005853 Mannose Unclear Unclear PMM2 [1]
MR005852 Mannose-6-phosphate Unclear Unclear MPI [1]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-galactosidase (bgaB) DME1155 Leptotrichia goodfellowii
A0A510JCD5_9FUSO
3.2.1.23
[2] , [3]
Beta-galactosidase (bgaB) DME1637 Leptotrichia buccalis
LACG_LEPBD
3.2.1.23
[2]
Glyceraldehyde-3-phosphate dehydrogenase (gap) DME1052 Lactobacillus acidophilus
A0A3A9YGB0_LACAI
1.2.1.-
[4]
hexokinase (HK) DMEN277 Homo sapiens Not Available Not Available [1]
Phosphomannomutase 2 (PMM2) DME0452 Homo sapiens
PMM2_HUMAN
5.4.2.8
[1]
Phosphomannose isomerase (MPI) DMEN278 Homo sapiens
MPI_HUMAN
5.3.1.8
[1]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [5]
⏷ Show the Full List of 7  DME(s)
References
1 Mannose metabolism: more than meets the eye. Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8.
2 Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592.
3 Leptotrichia species in human infections II. J Oral Microbiol. 2017 Sep 15;9(1):1368848.
4 Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.
5 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.

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