Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2284)
Drug Name
Ethoxzolamide
Synonyms
Ethamide; Ethoxazolamide; Ethoxyzolamide; Ethoxzolamide (EZA); Etoxzolamide; Glaucotensil; Mingoral; Redupresin; U-4191; ethoxzolamide; Cardrase; Cardrase (TN); Diuretic C; 2-Benzothiazolesulfonamide, 6-ethoxy-; 452-35-7; 6-(ethyloxy)-1,3-benzothiazole-2-sulfonamide; 6-Ethoxy-1,3-benzothiazole-2-sulfonamide; 6-Ethoxy-2-benzothiazolesulfonamide; 6-Ethoxy-benzothiazole-2-sulfonic acid amide; 6-Ethoxybenzo[d]thiazole-2-sulfonamide; 6-Ethoxybenzothiazole-2-sulfonamide; 6-Ethoxybenzothiazole-2-sulphonamide; 6-Ethoxyzolamide; 6-ethoxy-1,3-benzothiazole-2-sulfonamide; AI3-50805; BRN 0212240; C9H10N2O3S2; CHEMBL18; EINECS 207-199-5; EZL; HSDB 3268; MLS000028637; NSC 10679; UNII-Z52H4811WX
Indication Glaucoma [ICD11: 9C61] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 258.3 Topological Polar Surface Area 119
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
3295
PubChem SID
75836 ; 840267 ; 855751 ; 893338 ; 5242023 ; 7849499 ; 8152095 ; 10523205 ; 15213608 ; 24860121 ; 29215007 ; 29222433 ; 46509023 ; 46511452 ; 48415980 ; 49681475 ; 49890761 ; 50100966 ; 56422188 ; 57280084 ; 57280086 ; 57288316 ; 57304388 ; 57321712 ; 80657483 ; 85176911 ; 85306595 ; 87557627 ; 92308013 ; 92308213 ; 92729651 ; 95614375 ; 96021935 ; 99444198 ; 103048393 ; 103164710 ; 104171380 ; 104303092 ; 124587685 ; 124800633 ; 124883557 ; 124883558 ; 124897844 ; 125637519 ; 126671832 ; 128865742 ; 134337889 ; 134975323 ; 135378086 ; 137004941
ChEBI ID
CHEBI:101096
CAS Number
452-35-7
TTD Drug ID
D07INV
Formula
C9H10N2O3S2
Canonical SMILES
CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N
InChI
1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKey
OUZWUKMCLIBBOG-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Ethoxzolamide M1 PDM007175 N. A. Conjugation - N-Glucuronidation of sulfonamide 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1425 Eubacterium rectale Not Available Not Available [2]
References
1 Ethoxzolamide was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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