Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2807)
Drug Name
Lactose
Synonyms
Aletobiose; D-(+)-Lactose; D-Lactose; Fast-flo; Fast-flo Lactose; Galactinum; Lactin; Lactobiose; Lactose; Lactose [JAN]; Lactose anhydrous; Lactosum anhydricum; Milk sugar; Pharmatose 450M; Saccharum lactin; beta-D-Lactose; beta-Lactose; (+)-Lactose; .beta.-Lactose; 4-(beta-D-Galactosido)-D-glucose; 4-O-beta-D-Galactopyranosyl-D-glucose; 4-O-beta-D-Galactopyranosyl-beta-D-glucopyranose; 5965-66-2; D-Glucose, 4-O-beta-D-galactopyranosyl; EINECS 227-751-9; UNII-13Q3A43E0S; beta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-
Indication Lactose intolerance [ICD11: 5C61] Phase 1 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 342.3 Topological Polar Surface Area 190
Heavy Atom Count 23 Rotatable Bond Count 4
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 11
Cross-matching ID
PubChem CID
6134
ChEBI ID
CHEBI:36218
CAS Number
5965-66-2
Formula
C12H22O11
Canonical SMILES
C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O
InChI
1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1
InChIKey
GUBGYTABKSRVRQ-DCSYEGIMSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Lactose-6P DM003484
25244526
Unclear 1 [3]
Gal-6P DM003491 N. A. Unclear 2 [3]
Glucose DM003485
5793
Unclear 2 [3]
Glc-6P DM003486 N. A. Unclear 3 [3]
Tag-6P DM003492 N. A. Unclear 3 [3]
Fru-6P DM003487 N. A. Unclear 4 [3]
Tag-P2 DM003493 N. A. Unclear 4 [3]
DHAP DM003489 N. A. Unclear 5 [3]
Fru-P2 DM003488 N. A. Unclear 5 [3]
GA-3P DM003490 N. A. Unclear 5 [3]
DHAP DM003489 N. A. Unclear 6 [3]
GA-3P DM003490 N. A. Unclear 6 [3]
PEP DM003258
1005
Unclear 6 [3]
GA-3P DM003490 N. A. Unclear 7 [3]
PEP DM003258
1005
Unclear 7 [3]
PYR DM000331
107735
Unclear 7 [3]
Lactate DM003259
91435
Unclear 8 [3]
PEP DM003258
1005
Unclear 8 [3]
PYR DM000331
107735
Unclear 8 [3]
Lactate DM003259
91435
Unclear 9 [3]
PYR DM000331
107735
Unclear 9 [3]
Lactate DM003259
91435
Unclear 10 [3]
⏷ Show the Full List of 22  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR003937 Lactose Lactose-6P Unclear Unclear [3]
MR003938 Lactose-6P Glucose Unclear lacG [3]
MR003948 Lactose-6P Gal-6P Unclear Unclear [3]
MR003949 Gal-6P Tag-6P Unclear Unclear [3]
MR003939 Glucose Glc-6P Unclear Unclear [3]
MR003940 Glc-6P Fru-6P Unclear Unclear [3]
MR003950 Tag-6P Tag-P2 Unclear Unclear [3]
MR003941 Fru-6P Fru-P2 Unclear Unclear [3]
MR003951 Tag-P2 DHAP Unclear Unclear [3]
MR003952 Tag-P2 GA-3P Unclear Unclear [3]
MR014122 DHAP GA-3P Unclear Unclear [3]
MR003942 Fru-P2 DHAP Unclear Unclear [3]
MR003947 Fru-P2 GA-3P Unclear Unclear [3]
MR014119 GA-3P PEP Unclear Unclear [3]
MR003943 DHAP GA-3P Unclear Unclear [3]
MR014123 GA-3P PEP Unclear Unclear [3]
MR014120 PEP Pyruvate Unclear Unclear [3]
MR003944 GA-3P PEP Unclear Unclear [3]
MR014124 PEP Pyruvate Unclear Unclear [3]
MR014121 Pyruvate Lactate Unclear Unclear [3]
MR003945 PEP Pyruvate Unclear Unclear [3]
MR014125 Pyruvate Lactate Unclear Unclear [3]
MR003946 Pyruvate Lactate Unclear Unclear [3]
⏷ Show the Full List of 23 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-galactosidase (bgaB) DME1139 Victivallis vadensis
A0A2U1B4D0_9BACT
3.2.1.23
[2]
Beta-galactosidase (bgaB) DME1637 Leptotrichia buccalis
LACG_LEPBD
3.2.1.23
[3]
Cellobiose 2-epimerase (CE) DME1128 Faecalibacterium prausnitzii
A0A173SS24_9FIRM
5.1.3.11
[4]
Cellobiose 2-epimerase (CE) DME1130 Eubacterium siraeum
A0A174ZCD1_9FIRM
5.1.3.11
[4]
Cellobiose 2-epimerase (CE) DME1132 Lachnoclostridium phytofermentans
A9KK53_LACP7
5.1.3.11
[4]
Cellobiose 2-epimerase (CE) DME1133 Eubacterium cellulosolvens
CEEP_EUBCE
5.1.3.11
[4]
Cellobiose 2-epimerase (CE) DME1129 Coprococcus eutactus
A0A173Z970_9FIRM
5.1.3.11
[4]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [5]
⏷ Show the Full List of 8  DME(s)
References
1 ClinicalTrials.gov (NCT00599859) Effects of Lactose on Fecal Microflora
2 Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40.
3 Lactose metabolism in Streptococcus lactis: studies with a mutant lacking glucokinase and mannose-phosphotransferase activities
4 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.
5 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.

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