Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3371)
Drug Name
N1-methylnicotinamide
Synonyms
Trigonellinamide; 1-methylnicotinamide; N(1)-Methylnicotinamide; N1-Methylnicotinamide; 3-(Aminocarbonyl)-1-methylpyridinium; 1-Methyl nicotinamide; 3-carbamoyl-1-methylpyridinium; 3106-60-3; Pyridinium, 3-carbamoyl-1-methyl-; UNII-UM47085BXC; N(sup 1)-Methylnicotinamide; 3-carbamoyl-1-methylpyridin-1-ium; BRN 3540351; 1-methylpyridine-3-carboxamide; UM47085BXC; CHEBI:16797; 1-methylpyridin-1-ium-3-carboxamide; CHEMBL1209652; Trigonellamide; Pyridinium, 3-(aminocarbonyl)-1-methyl-; 1-methyl-3-carbamoylpyridinium; 8GC; I-methyl n
Indication Hypertriglyceridaemia [ICD11: 5C80] Phase 2/3 [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 137.16 Topological Polar Surface Area 47
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
457
ChEBI ID
CHEBI:16797
CAS Number
3106-60-3
TTD Drug ID
D0Q0FW
Formula
C7H9N2O+
Canonical SMILES
C[N+]1=CC=CC(=C1)C(=O)N
InChI
InChI=1S/C7H8N2O/c1-9-4-2-3-6(5-9)7(8)10/h2-5H,1H3,(H-,8,10)/p+1
InChIKey
LDHMAVIPBRSVRG-UHFFFAOYSA-O
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
N1-methyl-2-pyridone-5- carboxamide (2py) DM018471 N. A. Unclear - Unclear 1 [2]
N1-methyl-4-pyridone-3-carboxamide (4py) DM018472 N. A. Unclear - Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010495 N1-methylnicotinamide N1-methyl-2-pyridone-5- carboxamide (2py) Unclear - Unclear AOX1 [2]
MR010496 N1-methylnicotinamide N1-methyl-4-pyridone-3-carboxamide (4py) Unclear - Unclear AOX1 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Aldehyde oxidase (AOX1) DME0052 Homo sapiens
AOXA_HUMAN
1.2.3.1
[2]
References
1 ClinicalTrials.gov (NCT00519714) A Study to Evaluate the Lipid Regulating Effects of 1-Methylnicotinamide (1-MNA). U.S. National Institutes of Health.
2 N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?

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