Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5149)
Drug Name
Diethylcarbamazine
Synonyms
Bitirazine; Camin; Caracide; Carbamazine; Carbilazine; Caricide; Cypip; Decacide; Diaethylcarbamazinum; Diethylcarbamazinum; Dietilcarbamazina; Ethodryl; Luxuran; Notezine; Spatonin; Diethyl carbamazine; Ditrazine Base; Banocide (TN); Camin (TN); Carbilazine (TN); Caricide (TN); Cypip (TN); Diethylcarbamazine (INN); Diethylcarbamazine [INN:BAN]; Diethylcarbamazinum [INN-Latin]; Dietilcarbamazina [INN-Spanish]; Ethodryl (TN); FR-1031; Filaribits (TN); Forte (TN); Hetrazan (TN); Spatonin (TN); N,N-Diethyl-4-methyl-1-piperazinecarboxamide; N,N-diethyl-4-methylpiperazine-1-carboxamide; 1-Diethylcarbamyl-4-methylpiperazine; 84L
Indication Lymphatic filariasis [ICD11: 1F66] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 199.29 Topological Polar Surface Area 26.8
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
3052
ChEBI ID
CHEBI:4527
CAS Number
90-89-1
TTD Drug ID
D06RCB
Formula
C10H21N3O
Canonical SMILES
CCN(CC)C(=O)N1CCN(CC1)C
InChI
InChI=1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3
InChIKey
RCKMWOKWVGPNJF-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
1-Ethylcarbamyl-4-methylpiperazine DM015130
116045
Unclear - Unclear 1 [2]
Deaminated imatinib DM004307
53167
Unclear - Unclear 1 [2]
Diethylcarbamazine N-oxide DM015222
161840
Unclear - Unclear 1 [2]
Diethylcarbamylpiperazine DM015050
67067
Unclear - Unclear 1 [2]
Piperazine DM014875
4837
Unclear - Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR008632 Diethylcarbamazine Diethylcarbamazine N-oxide Unclear - Unclear Unclear [2]
MR008633 Diethylcarbamazine Piperazine Unclear - Unclear Unclear [2]
MR008634 Diethylcarbamazine N-Methylpiperazine Unclear - Unclear Unclear [2]
MR008635 Diethylcarbamazine Diethylcarbamylpiperazine Unclear - Unclear Unclear [2]
MR008636 Diethylcarbamazine 1-Ethylcarbamyl-4-methylpiperazine Unclear - Unclear Unclear [2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Dealkylation and N-oxidation in the metabolism of i-diethylcarbamyl-4-methylpiperazine in the rat

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